Literature DB >> 17191217

Lipoxygenase inhibitors: a comparative QSAR study review and evaluation of new QSARs.

Eleni Pontiki1, Dimitra Hadjipavlou-Litina.   

Abstract

This paper contains a quantitative structure activity relationship (QSAR) study for lipoxygenase (LO) inhibitors. It reveals that in almost all cases, the clog P parameter plays an important part in the QSARs (linear or bilinear model). In some cases the steric factors such as the overall molar refractivity (CMR) or the substituents molar refractivity (MR) (linear or parabola) are important. Electronic effects are comparatively unimportant. The study shows that log P as calculated from the Clog P program is suitable for this form of QSAR study.

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Year:  2008        PMID： 17191217     DOI： 10.1002/med.20099

Source DB:  PubMed          Journal:  Med Res Rev        ISSN： 0198-6325            Impact factor:   12.944


  10 in total

1.  Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.

Authors:  Carolina Mascayano; Victoria Espinosa; Silvia Sepúlveda-Boza; Eric K Hoobler; Steve Perry; Giovanni Diaz; Theodore R Holman
Journal:  Chem Biol Drug Des       Date:  2014-11-28       Impact factor: 2.817

Review 2.  Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors.

Authors:  Polamarasetty Aparoy; Kakularam Kumar Reddy; Pallu Reddanna
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

3.  Clicked cinnamic/caffeic esters and amides as radical scavengers and 5-lipoxygenase inhibitors.

Authors:  Jérémie A Doiron; Benoît Métayer; Ryan R Richard; Dany Desjardins; Luc H Boudreau; Natalie A Levesque; Jacques Jean-François; Samuel J Poirier; Marc E Surette; Mohamed Touaibia
Journal:  Int J Med Chem       Date:  2014-02-18

4.  Computational Analysis of LOX1 Inhibition Identifies Descriptors Responsible for Binding Selectivity.

Authors:  Chrysoula Gousiadou; Irene Kouskoumvekaki
Journal:  ACS Omega       Date:  2018-02-26

5.  Multifunctional Cinnamic Acid Derivatives.

Authors:  Aikaterini Peperidou; Eleni Pontiki; Dimitra Hadjipavlou-Litina; Efstathia Voulgari; Konstantinos Avgoustakis
Journal:  Molecules       Date:  2017-07-25       Impact factor: 4.411

6.  Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX.

Authors:  Aikaterini Peperidou; Silvia Bua; Murat Bozdag; Dimitra Hadjipavlou-Litina; Claudiu T Supuran
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

7.  Multitarget molecular hybrids of cinnamic acids.

Authors:  Aikaterini Peperidou; Dorothea Kapoukranidou; Christos Kontogiorgis; Dimitra Hadjipavlou-Litina
Journal:  Molecules       Date:  2014-12-02       Impact factor: 4.411

8.  Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.

Authors:  Eleni Pontiki; Dimitra Hadjipavlou-Litina
Journal:  Molecules       Date:  2018-12-20       Impact factor: 4.411

9.  Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants.

Authors:  I Perković; I Butula; M Kralj; I Martin-Kleiner; J Balzarini; D Hadjipavlou-Litina; A-M Katsori; B Zorc
Journal:  Eur J Med Chem       Date:  2012-03-03       Impact factor: 6.514

10.  2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities.

Authors:  Olympia Kouzi; Eleni Pontiki; Dimitra Hadjipavlou-Litina
Journal:  Molecules       Date:  2019-12-03       Impact factor: 4.411
  10 in total

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