BACKGROUND: Coinfection with hepatitis C virus (HCV) is a poor prognostic factor for human immunodeficiency virus (HIV)-infected patients. We examined whether the increased mortality in these patients is partly explained by a familial excess risk of death. METHODS: Danish HIV-infected patients who had had at least 1 HCV test were included (n=3531). In addition, 336,652 population control subjects matched for sex, age, and residency were identified from the Danish Civil Registration System. For both HIV-infected patients and population control subjects, we identified all siblings born after 1951, with dates of death or emigration. Siblings of HIV-infected patients were classified according to the patients' HCV serostatus. Survival after age 20 years was compared among the groups of siblings. RESULTS: We identified 437 siblings of HIV/HCV-coinfected patients, 1856 siblings of HIV-monoinfected patients, and 285,509 siblings of population control subjects. Mortality was substantially higher in siblings of HIV/HCV-coinfected patients than in either siblings of HIV-monoinfected patients (mortality rate ratio [MRR], 2.97 [95% confidence interval {CI}, 1.98-4.45]) or siblings of control subjects (MRR, 4.23 [95% CI, 3.09-5.79]). Siblings of HIV-monoinfected patients had slightly higher mortality (MRR, 1.43 [95% CI, 1.10-1.85]) than siblings of control subjects. CONCLUSIONS: HCV infection is a marker of familial factors that affect the survival of HIV-infected patients independently of the pathogenicity of HCV.
BACKGROUND: Coinfection with hepatitis C virus (HCV) is a poor prognostic factor for human immunodeficiency virus (HIV)-infectedpatients. We examined whether the increased mortality in these patients is partly explained by a familial excess risk of death. METHODS: Danish HIV-infectedpatients who had had at least 1 HCV test were included (n=3531). In addition, 336,652 population control subjects matched for sex, age, and residency were identified from the Danish Civil Registration System. For both HIV-infectedpatients and population control subjects, we identified all siblings born after 1951, with dates of death or emigration. Siblings of HIV-infectedpatients were classified according to the patients' HCV serostatus. Survival after age 20 years was compared among the groups of siblings. RESULTS: We identified 437 siblings of HIV/HCV-coinfectedpatients, 1856 siblings of HIV-monoinfectedpatients, and 285,509 siblings of population control subjects. Mortality was substantially higher in siblings of HIV/HCV-coinfectedpatients than in either siblings of HIV-monoinfectedpatients (mortality rate ratio [MRR], 2.97 [95% confidence interval {CI}, 1.98-4.45]) or siblings of control subjects (MRR, 4.23 [95% CI, 3.09-5.79]). Siblings of HIV-monoinfectedpatients had slightly higher mortality (MRR, 1.43 [95% CI, 1.10-1.85]) than siblings of control subjects. CONCLUSIONS:HCV infection is a marker of familial factors that affect the survival of HIV-infectedpatients independently of the pathogenicity of HCV.
Authors: Rebecca K Lodwick; Caroline A Sabin; Kholoud Porter; Bruno Ledergerber; Ard van Sighem; Alessandro Cozzi-Lepri; Pavel Khaykin; Amanda Mocroft; Lisa Jacobson; Stephane De Wit; Niels Obel; Antonella Castagna; Jan-Christian Wasmuth; John Gill; Marina B Klein; Stephen Gange; Melchor Riera; Cristina Mussini; Félix Gutiérrez; Giota Touloumi; Patrizia Carrieri; Jodie L Guest; Norbert H Brockmeyer; Andrew N Phillips Journal: Lancet Date: 2010-07-15 Impact factor: 79.321
Authors: Guy de Bruyn; Amalia Magaret; Jared M Baeten; Jairam R Lingappa; Patrick Ndase; Connie Celum; Anna Wald Journal: BMC Infect Dis Date: 2012-10-30 Impact factor: 3.090
Authors: Niels Obel; Hanne Reinholdt; Lars H Omland; Frederik Engsig; Henrik T Sørensen; Ann-Brit E Hansen Journal: BMC Med Res Methodol Date: 2008-04-25 Impact factor: 4.615