| Literature DB >> 17190645 |
J A Kralovec1, K L Metera, J R Kumar, L V Watson, G S Girouard, Y Guan, R I Carr, C J Barrow, H S Ewart.
Abstract
Our proprietary preparation obtained by extraction of Chlorella pyrenoidosa cells, ONC-107 (Respondin), was recently found to selectively boost antibody response to the influenza vaccine in a human clinical trial. Respondin is a potent stimulator of mouse B cell proliferation and an activator of macrophages. Bioactivity-guided resolution concluded that Respondin is composed of a mixture of immunostimulatory principles of different chemical nature. A combination of size exclusion, anion exchange and hydrophobic interaction chromatography revealed that the bulk of the immunostimulatory activity resides in polysaccharide/protein complexes with molecular masses larger than 100 kDa that are composed primarily of galactose, rhamnose and arabinose.Entities:
Mesh：
Substances：
Year: 2005 PMID： 17190645 DOI： 10.1016/j.phymed.2005.09.002
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340