| Literature DB >> 17190605 |
Marie Gottar1, Vanessa Gobert, Alexey A Matskevich, Jean-Marc Reichhart, Chengshu Wang, Tariq M Butt, Marcia Belvin, Jules A Hoffmann, Dominique Ferrandon.
Abstract
The Drosophila immune system discriminates between various types of infections and activates appropriate signal transduction pathways to combat the invading microorganisms. The Toll pathway is required for the host response against fungal and most Gram-positive bacterial infections. The sensing of Gram-positive bacteria is mediated by the pattern recognition receptors PGRP-SA and GNBP1 that cooperate to detect the presence of infections in the host. Here, we report that GNBP3 is a pattern recognition receptor that is required for the detection of fungal cell wall components. Strikingly, we find that there is a second, parallel pathway acting jointly with GNBP3. The Drosophila Persephone protease activates the Toll pathway when proteolytically matured by the secreted fungal virulence factor PR1. Thus, the detection of fungal infections in Drosophila relies both on the recognition of invariant microbial patterns and on monitoring the effects of virulence factors on the host.Entities:
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Year: 2006 PMID： 17190605 PMCID： PMC1865096 DOI： 10.1016/j.cell.2006.10.046
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582