Literature DB >> 17190470

Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandiflora.

Bharat P Bashyal1, Steven P McLaughlin, A A Leslie Gunatilaka.   

Abstract

Three new delta-elemanolide-type sesquiterpene lactones, zinagrandinolides A-C (1-3), and the known delta-elemanolide 4 have been isolated by a bioassay-guided fractionation of a cytotoxic hexane extract of the aerial parts of Zinnia grandiflora. The structures of 1-3 were determined on the basis of high-resolution mass and NMR data. All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17190470     DOI： 10.1021/np0603626

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  3 in total

1.  Halocarbocyclization entry into the oxabicyclo[4.3.1]decyl exomethylene-δ-lactone cores of linearifolin and zaluzanin A: exploiting combinatorial catalysis.

Authors:  Sandeep K Ginotra; Jacob A Friest; David B Berkowitz
Journal:  Org Lett       Date:  2012-02-08       Impact factor: 6.005

2.  Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum.

Authors:  Jixun Zhan; Anna M Burns; Manping X Liu; Stanley H Faeth; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2007-02-08       Impact factor: 4.050

3.  Chemical Profile and Antioxidant Activity of Zinnia elegans Jacq. Fractions.

Authors:  Ana Flavia Burlec; Łukasz Pecio; Cornelia Mircea; Oana Cioancă; Andreia Corciovă; Alina Nicolescu; Wiesław Oleszek; Monica Hăncianu
Journal:  Molecules       Date:  2019-08-13       Impact factor: 4.411
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.