| Literature DB >> 17190461 |
Gottumukkala V Subbaraju1, Mulabagal Vanisree, Chirravuri V Rao, Chillara Sivaramakrishna, Pratha Sridhar, Bolleddula Jayaprakasam, Muraleedharan G Nair.
Abstract
A new dimeric withanolide, ashwagandhanolide (1), was isolated from the roots of an Ayurvedic medicinal herb, Withania somnifera. A detailed spectroscopic evaluation revealed its identity as a dimer with an unusual thioether linkage. Compound 1 displayed growth inhibition against human gastric (AGS), breast (MCF-7), central nervous system (SF-268), colon (HCT-116), and lung (NCI H460) cancer cell lines, with IC50 values in the range 0.43-1.48 microg/mL. In addition, it inhibited lipid peroxidation and the activity of the enzyme cyclooxygenase-2 in vitro.Entities:
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Year: 2006 PMID： 17190461 DOI： 10.1021/np060147p
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050