| Literature DB >> 17189691 |
Simona M Ceccarelli1, Georg Jaeschke, Bernd Buettelmann, Jörg Huwyler, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Richard Porter, Will Spooren, Eric Vieira.
Abstract
A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable pharmacokinetic properties and are active in an in vivo model of anxiety.Entities:
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Year: 2006 PMID： 17189691 DOI： 10.1016/j.bmcl.2006.12.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823