Literature DB >> 17189490

Endoplasmic reticulum retention signal-dependent glycylation of the Hsp70/Grp170-related Pgp1p in Tetrahymena.

Rong Xie1, Kathleen M Clark, Martin A Gorovsky.   

Abstract

Glycylation is an uncommon posttranslational modification. It has been found that tubulin glycylation is essential for cell survival in Tetrahymena. Here we describe PGP1, a Tetrahymena gene encoding an Hsp70 homologue that is a novel glycylated protein. Pgp1p is a conserved glycoprotein that localizes within the lumen of the endoplasmic reticulum (ER). We demonstrate that PGP1 is essential for viability and present evidence that both glycosylation and ER retention are necessary but not sufficient for glycylation.

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Year:  2006        PMID： 17189490      PMCID： PMC1828932          DOI： 10.1128/EC.00366-06

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  35 in total

1.  Both carboxy-terminal tails of alpha- and beta-tubulin are essential, but either one will suffice.

Authors:  Jianming Duan; Martin A Gorovsky
Journal:  Curr Biol       Date:  2002-02-19       Impact factor: 10.834

Review 2.  Quality control in the endoplasmic reticulum.

Authors:  Lars Ellgaard; Ari Helenius
Journal:  Nat Rev Mol Cell Biol       Date:  2003-03       Impact factor: 94.444

3.  Coordinated activation of Hsp70 chaperones.

Authors:  Gregor J Steel; Donna M Fullerton; John R Tyson; Colin J Stirling
Journal:  Science       Date:  2004-01-02       Impact factor: 47.728

4.  Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

Authors:  Carsten Janke; Krzysztof Rogowski; Dorota Wloga; Catherine Regnard; Andrey V Kajava; Jean-Marc Strub; Nevzat Temurak; Juliette van Dijk; Dominique Boucher; Alain van Dorsselaer; Swati Suryavanshi; Jacek Gaertig; Bernard Eddé
Journal:  Science       Date:  2005-05-12       Impact factor: 47.728

5.  The Giardia duodenalis 14-3-3 protein is post-translationally modified by phosphorylation and polyglycylation of the C-terminal tail.

Authors:  Marco Lalle; Anna Maria Salzano; Marco Crescenzi; Edoardo Pozio
Journal:  J Biol Chem       Date:  2005-12-20       Impact factor: 5.157

6.  The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin.

Authors:  H Y Lin; P Masso-Welch; Y P Di; J W Cai; J W Shen; J R Subjeck
Journal:  Mol Biol Cell       Date:  1993-11       Impact factor: 4.138

Review 7.  The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s.

Authors:  D P Easton; Y Kaneko; J R Subjeck
Journal:  Cell Stress Chaperones       Date:  2000-10       Impact factor: 3.667

8.  Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF.

Authors:  X D Liu; P C Liu; N Santoro; D J Thiele
Journal:  EMBO J       Date:  1997-11-03       Impact factor: 11.598

9.  A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila.

Authors:  Yuhua Shang; Xiaoyuan Song; Josephine Bowen; Robert Corstanje; Yan Gao; Jacek Gaertig; Martin A Gorovsky
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-12       Impact factor: 11.205

Review 10.  N-linked oligosaccharides as outfitters for glycoprotein folding, form and function.

Authors:  Nivedita Mitra; Sharmistha Sinha; Thirumalai N C Ramya; Avadhesha Surolia
Journal:  Trends Biochem Sci       Date:  2006-02-10       Impact factor: 13.807
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  10 in total

Review 1.  Conservation and innovation in Tetrahymena membrane traffic: proteins, lipids, and compartments.

Authors:  Alejandro D Nusblat; Lydia J Bright; Aaron P Turkewitz
Journal:  Methods Cell Biol       Date:  2012       Impact factor: 1.441

2.  Microtubule glycylation promotes attachment of basal bodies to the cell cortex.

Authors:  Anthony D Junker; Adam W J Soh; Eileen T O'Toole; Janet B Meehl; Mayukh Guha; Mark Winey; Jerry E Honts; Jacek Gaertig; Chad G Pearson
Journal:  J Cell Sci       Date:  2019-08-07       Impact factor: 5.285

3.  TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1.

Authors:  Koji Ikegami; Daisuke Horigome; Masahiro Mukai; Itamar Livnat; Grant R MacGregor; Mitsutoshi Setou
Journal:  FEBS Lett       Date:  2008-03-10       Impact factor: 4.124

4.  The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae.

Authors:  Tomas J Poklepovich; Mauro A Rinaldi; Mariela L Tomazic; Nicolas O Favale; Aaron P Turkewitz; Clara B Nudel; Alejandro D Nusblat
Journal:  Steroids       Date:  2012-09-12       Impact factor: 2.668

5.  Different effects of Tetrahymena IFT172 domains on anterograde and retrograde intraflagellar transport.

Authors:  Che-Chia Tsao; Martin A Gorovsky
Journal:  Mol Biol Cell       Date:  2008-01-16       Impact factor: 4.138

Review 6.  The tubulin code: molecular components, readout mechanisms, and functions.

Authors:  Carsten Janke
Journal:  J Cell Biol       Date:  2014-08-18       Impact factor: 10.539

7.  Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity.

Authors:  Jenny Calow; Anna-Janina Behrens; Sonja Mader; Ulrike Bockau; Weston B Struwe; David J Harvey; Kai U Cormann; Marc M Nowaczyk; Karin Loser; Daniel Schinor; Marcus W W Hartmann; Max Crispin
Journal:  MAbs       Date:  2016-09-03       Impact factor: 5.857

8.  Tubulin glycylation controls primary cilia length.

Authors:  Sudarshan Gadadhar; Hala Dadi; Satish Bodakuntla; Anne Schnitzler; Ivan Bièche; Filippo Rusconi; Carsten Janke
Journal:  J Cell Biol       Date:  2017-07-07       Impact factor: 10.539

9.  An aspartyl cathepsin, CTH3, is essential for proprotein processing during secretory granule maturation in Tetrahymena thermophila.

Authors:  Santosh Kumar; Joseph S Briguglio; Aaron P Turkewitz
Journal:  Mol Biol Cell       Date:  2014-06-18       Impact factor: 4.138

10.  Whole Genome Sequencing Identifies a Novel Factor Required for Secretory Granule Maturation in Tetrahymena thermophila.

Authors:  Cassandra Kontur; Santosh Kumar; Xun Lan; Jonathan K Pritchard; Aaron P Turkewitz
Journal:  G3 (Bethesda)       Date:  2016-08-09       Impact factor: 3.154
  10 in total

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