Literature DB >> 1718872

Characterization of murine monoclonal antibodies that recognize defined epitopes of pertussis toxin and neutralize its toxic effect on Chinese hamster ovary cells.

M J Walker1, J Wehland, K N Timmis, B Raupach, M A Schmidt.   

Abstract

Three murine monoclonal antibodies (MAb), E19, E205, and E251, raised against pertussis toxin reacted in Western blots (immunoblots) with the S1, S4, and S2-S3 subunits, respectively, and neutralized the Chinese hamster ovary cell-clustering activity of pertussis toxin. MAb E251 recognized a linear synthetic peptide corresponding to amino acids 107 to 120 of the S2 subunit, suggesting a role for this region in receptor binding.

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Year:  1991        PMID： 1718872      PMCID： PMC259023          DOI： 10.1128/iai.59.11.4249-4251.1991

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  26 in total

1.  Identification of linear B-cell determinants of pertussis toxin associated with the receptor recognition site of the S3 subunit.

Authors:  M A Schmidt; B Raupach; M Szulczynski; J Marzillier
Journal:  Infect Immun       Date:  1991-04       Impact factor: 3.441

2.  The interaction between pertussis toxin and 10 monoclonal antibodies.

Authors:  C Schou; M Au-Jensen; I Heron
Journal:  Acta Pathol Microbiol Immunol Scand C       Date:  1987-10

3.  Monoclonal antibodies that define neutralizing epitopes of pertussis toxin: conformational dependence and epitope mapping.

Authors:  A B Lang; M T Ganss; S J Cryz
Journal:  Infect Immun       Date:  1989-09       Impact factor: 3.441

4.  Inhibition of pertussis toxin binding to model receptors by antipeptide antibodies directed at an antigenic domain of the S2 subunit.

Authors:  M A Schmidt; W Schmidt
Journal:  Infect Immun       Date:  1989-12       Impact factor: 3.441

5.  Mapping of linear B-cell epitopes of the S2 subunit of pertussis toxin.

Authors:  W Schmidt; M A Schmidt
Journal:  Infect Immun       Date:  1989-02       Impact factor: 3.441

6.  Monoclonal antibodies to pertussis toxin: utilization as probes of toxin function.

Authors:  J G Kenimer; K J Kim; P G Probst; C R Manclark; D G Burstyn; J L Cowell
Journal:  Hybridoma       Date:  1989-02

7.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

Review 8.  Pertussis vaccine: present status and future prospects.

Authors:  A Robinson; L I Irons; L A Ashworth
Journal:  Vaccine       Date:  1985-03       Impact factor: 3.641

9.  Characterization of monoclonal antibodies against Shiga-like toxin from Escherichia coli.

Authors:  N A Strockbine; L R Marques; R K Holmes; A D O'Brien
Journal:  Infect Immun       Date:  1985-12       Impact factor: 3.441

10.  Turnover of the carboxy-terminal tyrosine of alpha-tubulin and means of reaching elevated levels of detyrosination in living cells.

Authors:  J Wehland; K Weber
Journal:  J Cell Sci       Date:  1987-09       Impact factor: 5.285
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  8 in total

1.  Stable expression of pertussis toxin in Bordetella bronchiseptica under the control of a tightly regulated promoter.

Authors:  A Suarez; L H Staendner; M Rohde; G Piatti; K N Timmis; C A Guzmán
Journal:  Appl Environ Microbiol       Date:  1997-01       Impact factor: 4.792

2.  Construction of minitransposons for constitutive and inducible expression of pertussis toxin in bvg-negative Bordetella bronchiseptica.

Authors:  M J Walker; M Rohde; J Wehland; K N Timmis
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

Review 3.  Progress towards recombinant anti-infective antibodies.

Authors:  Jennifer C Pai; Jamie N Sutherland; Jennifer A Maynard
Journal:  Recent Pat Antiinfect Drug Discov       Date:  2009-01

4.  Identification of B-cell epitopes on the S4 subunit of pertussis toxin.

Authors:  P H Ibsen; A Holm; J W Petersen; C E Olsen; I Heron
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441

5.  Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit.

Authors:  M J Walker; M Rohde; K N Timmis; C A Guzmán
Journal:  Infect Immun       Date:  1992-10       Impact factor: 3.441

6.  Antibody responses in the serum and respiratory tract of mice following oral vaccination with liposomes coated with filamentous hemagglutinin and pertussis toxoid.

Authors:  C A Guzman; G Molinari; M W Fountain; M Rohde; K N Timmis; M J Walker
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

Review 7.  Monoclonal antibodies and toxins--a perspective on function and isotype.

Authors:  Siu-Kei Chow; Arturo Casadevall
Journal:  Toxins (Basel)       Date:  2012-06-11       Impact factor: 4.546

8.  Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxin.

Authors:  Y Lobet; C Feron; G Dequesne; E Simoen; P Hauser; C Locht
Journal:  J Exp Med       Date:  1993-01-01       Impact factor: 14.307
  8 in total

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