Literature DB >> 1718856

Localization of a T-cell epitope within the nucleocapsid protein of avian coronavirus.

A M Boots1, J G Kusters, J M van Noort, K A Zwaagstra, E Rijke, B A van der Zeijst, E J Hensen.   

Abstract

In a previous study, two murine T-cell hybridomas generated after immunization with infectious bronchitis virus (IBV) were shown to be responsive to the internally localized viral nucleocapsid protein. In the present study, the antigenic determinants were mapped using recombinant expression products and synthetic peptides. Both hybridomas recognized the region spanning amino acid residues 71 to 78 of the nucleocapsid protein. The experimentally determined epitope corresponded with predicted motifs. Both an I-Ed binding motif and a predicted cleavage site for the aspartyl protease cathepsin D were contained within the sequence. The epitope was shown to prime cellular immune responses to IBV in the chicken.

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Year:  1991        PMID： 1718856      PMCID： PMC1384663     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  34 in total

1.  Helper T-cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptide.

Authors:  K B Cease; H Margalit; J L Cornette; S D Putney; W G Robey; C Ouyang; H Z Streicher; P J Fischinger; R C Gallo; C DeLisi
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

2.  The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.

Authors:  A R Townsend; J Rothbard; F M Gotch; G Bahadur; D Wraith; A J McMichael
Journal:  Cell       Date:  1986-03-28       Impact factor: 41.582

3.  The molecular basis of the requirement for antigen processing of pigeon cytochrome c prior to T cell activation.

Authors:  Z Kovac; R H Schwartz
Journal:  J Immunol       Date:  1985-05       Impact factor: 5.422

4.  Characterization of a naturally processed MHC class II-restricted T-cell determinant of hen egg lysozyme.

Authors:  S Demotz; H M Grey; E Appella; A Sette
Journal:  Nature       Date:  1989-12-07       Impact factor: 49.962

5.  Fine specificity of T cell recognition of the same peptide in association with different I-A molecules.

Authors:  S J Brett; K B Cease; C S Ouyang; J A Berzofsky
Journal:  J Immunol       Date:  1989-08-01       Impact factor: 5.422

6.  Strategies for epitope analysis using peptide synthesis.

Authors:  H M Geysen; S J Rodda; T J Mason; G Tribbick; P G Schoofs
Journal:  J Immunol Methods       Date:  1987-09-24       Impact factor: 2.303

7.  A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules.

Authors:  F Sinigaglia; M Guttinger; J Kilgus; D M Doran; H Matile; H Etlinger; A Trzeciak; D Gillessen; J R Pink
Journal:  Nature       Date:  1988 Dec 22-29       Impact factor: 49.962

8.  Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides.

Authors:  R Van der Zee; W Van Eden; R H Meloen; A Noordzij; J D Van Embden
Journal:  Eur J Immunol       Date:  1989-01       Impact factor: 5.532

9.  The peplomer protein sequence of the M41 strain of coronavirus IBV and its comparison with Beaudette strains.

Authors:  H G Niesters; J A Lenstra; W J Spaan; A J Zijderveld; N M Bleumink-Pluym; F Hong; G J van Scharrenburg; M C Horzinek; B A van der Zeijst
Journal:  Virus Res       Date:  1986-08       Impact factor: 3.303

10.  Phylogeny of antigenic variants of avian coronavirus IBV.

Authors:  J G Kusters; H G Niesters; J A Lenstra; M C Horzinek; B A van der Zeijst
Journal:  Virology       Date:  1989-03       Impact factor: 3.616
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  24 in total

1.  The carboxyl-terminal 120-residue polypeptide of infectious bronchitis virus nucleocapsid induces cytotoxic T lymphocytes and protects chickens from acute infection.

Authors:  S H Seo; L Wang; R Smith; E W Collisson
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

2.  Specific cytotoxic T lymphocytes are involved in in vivo clearance of infectious bronchitis virus.

Authors:  S H Seo; E W Collisson
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

Review 3.  Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus.

Authors:  Susan R Weiss; Sonia Navas-Martin
Journal:  Microbiol Mol Biol Rev       Date:  2005-12       Impact factor: 11.056

4.  Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus.

Authors:  Tae Woo Kim; Jin Hyup Lee; Chien-Fu Hung; Shiwen Peng; Richard Roden; Mei-Cheng Wang; Raphael Viscidi; Ya-Chea Tsai; Liangmei He; Pei-Jer Chen; David A K Boyd; T-C Wu
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

5.  Identification of a novel linear B-cell epitope in the M protein of avian infectious bronchitis coronaviruses.

Authors:  Junji Xing; Shengwang Liu; Zongxi Han; Yuhao Shao; Huixin Li; Xiangang Kong
Journal:  J Microbiol       Date:  2009-10-24       Impact factor: 3.422

6.  Seroprevalence of turkey coronavirus in North American turkeys determined by a newly developed enzyme-linked immunosorbent assay based on recombinant antigen.

Authors:  Maged H Gomaa; Dongwan Yoo; Davor Ojkic; John R Barta
Journal:  Clin Vaccine Immunol       Date:  2008-10-29

7.  The S1 glycoprotein but not the N or M proteins of avian infectious bronchitis virus induces protection in vaccinated chickens.

Authors:  J Ignjatovic; L Galli
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

8.  Identification of CD8+ cytotoxic T lymphocyte epitopes from porcine reproductive and respiratory syndrome virus matrix protein in BALB/c mice.

Authors:  Weijun Zhang; Yan Lin; Yu Bai; Tiegang Tong; Qun Wang; Nihong Liu; Guangliang Liu; Yihong Xiao; Tao Yang; Zhigao Bu; Guangzhi Tong; Donglai Wu
Journal:  Virol J       Date:  2011-05-30       Impact factor: 4.099

9.  Identification of Novel T-Cell Epitopes on Infectious Bronchitis Virus N Protein and Development of a Multi-epitope Vaccine.

Authors:  Yifeng Qin; Kaihang Tu; Qingyuan Teng; Delan Feng; Ye Zhao; Guozhong Zhang
Journal:  J Virol       Date:  2021-08-10       Impact factor: 5.103

10.  Prediction and identification of T cell epitopes in the H5N1 influenza virus nucleoprotein in chicken.

Authors:  Yanxia Hou; Yingying Guo; Chunyan Wu; Nan Shen; Yongping Jiang; Jingfei Wang
Journal:  PLoS One       Date:  2012-06-20       Impact factor: 3.240
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