Literature DB >> 17188427

Tumor-suppressive activity of retinoic acid receptor-beta in cancer.

Xiao-Chun Xu1.   

Abstract

Retinoids, a group of structural and functional analogs of vitamin A, are known to regulate a large number of essential biological processes and to suppress carcinogenesis. The effects of retinoids are mainly mediated by nuclear retinoid receptors, which include retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Each receptor has three subtypes (alpha, beta, and gamma) and each subtype has different isoforms. Retinoic acid receptor-beta (RAR-beta) has four isoforms that have different affinities to retinoids and different biological functions. Loss of expression of RAR-beta(2) during cancer development is associated with tumorigenesis and retinoid resistance; induction of its expression, on the other hand, can suppress carcinogenesis. Expression of another isoform, RAR-beta(4), is increased in various types of cancer. RAR-beta(4) transgenic mice develop hyperplasia and neoplasia in various tissues, and induction of RAR-beta(4) expression increases the growth of tumor cells that do not express RAR-beta(2). Future studies will focus on molecular pathways involving RAR-beta(2) and the role of RAR-beta(4) in cancer development.

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Year:  2006        PMID： 17188427      PMCID： PMC2562790          DOI： 10.1016/j.canlet.2006.11.019

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  106 in total

1.  Aberrant promoter methylation of p16(INK4a), RARB2 and SEMA3B in bronchial aspirates from patients with suspected lung cancer.

Authors:  Hans J Grote; Viola Schmiemann; Helene Geddert; Ulrich P Rohr; Rainer Kappes; Helmut E Gabbert; Alfred Böcking
Journal:  Int J Cancer       Date:  2005-09-20       Impact factor: 7.396

2.  Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck.

Authors:  W K Hong; S M Lippman; L M Itri; D D Karp; J S Lee; R M Byers; S P Schantz; A M Kramer; R Lotan; L J Peters
Journal:  N Engl J Med       Date:  1990-09-20       Impact factor: 91.245

3.  Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer.

Authors:  Jie Huang; Zheng D Liang; Tsung-Teh Wu; Ashraful Hoque; Hongli Chen; Yan Jiang; Hongfu Zhang; Xiao-Chun Xu
Journal:  Cancer Res       Date:  2007-02-15       Impact factor: 12.701

4.  EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups.

Authors:  N van Zandwijk; O Dalesio; U Pastorino; N de Vries; H van Tinteren
Journal:  J Natl Cancer Inst       Date:  2000-06-21       Impact factor: 13.506

5.  Lung tumors in mice expressing an antisense RARbeta2 transgene.

Authors:  J Bérard; F Laboune; M Mukuna; S Massé; R Kothary; W E Bradley
Journal:  FASEB J       Date:  1996-07       Impact factor: 5.191

6.  Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group.

Authors:  T E Moon; N Levine; B Cartmel; J L Bangert; S Rodney; Q Dong; Y M Peng; D S Alberts
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  1997-11       Impact factor: 4.254

7.  Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells.

Authors:  B Houle; C Rochette-Egly; W E Bradley
Journal:  Proc Natl Acad Sci U S A       Date:  1993-02-01       Impact factor: 11.205

8.  Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis.

Authors:  S M Lippman; J G Batsakis; B B Toth; R S Weber; J J Lee; J W Martin; G L Hays; H Goepfert; W K Hong
Journal:  N Engl J Med       Date:  1993-01-07       Impact factor: 91.245

9.  Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine.

Authors:  Fiona McGregor; Alessandra Muntoni; Janis Fleming; Judith Brown; David H Felix; D Gordon MacDonald; E Kenneth Parkinson; Paul R Harrison
Journal:  Cancer Res       Date:  2002-08-15       Impact factor: 12.701

10.  Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial.

Authors:  F L Meyskens; E Surwit; T E Moon; J M Childers; J R Davis; R T Dorr; C S Johnson; D S Alberts
Journal:  J Natl Cancer Inst       Date:  1994-04-06       Impact factor: 13.506
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  37 in total

1.  Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice.

Authors:  Jorge Gutiérrez; Enrique García-Villa; Rodolfo Ocadiz-Delgado; Enoc M Cortés-Malagón; Juan Vázquez; Alejandra Roman-Rosales; Elizabeth Alvarez-Rios; Haydar Celik; Marta C Romano; Aykut Üren; Paul F Lambert; Patricio Gariglio
Journal:  Mol Cell Biochem       Date:  2015-07-15       Impact factor: 3.396

Review 2.  Role of retinoids in the prevention and treatment of colorectal cancer.

Authors:  Catherine C Applegate; Michelle A Lane
Journal:  World J Gastrointest Oncol       Date:  2015-10-15

3.  AEG-1 regulates retinoid X receptor and inhibits retinoid signaling.

Authors:  Jyoti Srivastava; Chadia L Robertson; Devaraja Rajasekaran; Rachel Gredler; Ayesha Siddiq; Luni Emdad; Nitai D Mukhopadhyay; Shobha Ghosh; Phillip B Hylemon; Gregorio Gil; Khalid Shah; Deepak Bhere; Mark A Subler; Jolene J Windle; Paul B Fisher; Devanand Sarkar
Journal:  Cancer Res       Date:  2014-08-15       Impact factor: 12.701

4.  Effects of beta-carotene supplementation on molecular markers of lung carcinogenesis in male smokers.

Authors:  Margaret E Wright; Steve D Groshong; Kirsti Husgafvel-Pursiainen; Erin Genova; M Scott Lucia; Henrik Wolff; Jarmo Virtamo; Demetrius Albanes
Journal:  Cancer Prev Res (Phila)       Date:  2010-05-18

Review 5.  Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation.

Authors:  Micah G Donovan; Spencer N Wren; Mikia Cenker; Ornella I Selmin; Donato F Romagnolo
Journal:  Br J Pharmacol       Date:  2020-01-26       Impact factor: 8.739

6.  Detection of retinoid receptors in non-neoplastic canine lymph nodes and in lymphoma.

Authors:  Carlos H de Mello Souza; Victor E O Valli; Barbara E Kitchell
Journal:  Can Vet J       Date:  2014-01       Impact factor: 1.008

7.  Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome.

Authors:  Aurélie Perraud; Michelle Nouaille; Hussein Akil; Daniel Petit; François Labrousse; Marie-Odile Jauberteau; Muriel Mathonnet
Journal:  Exp Ther Med       Date:  2011-03-21       Impact factor: 2.447

8.  A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.

Authors:  Xiao-Han Tang; Martin Albert; Theresa Scognamiglio; Lorraine J Gudas
Journal:  Cancer Prev Res (Phila)       Date:  2009-12-01

9.  Signalling with retinoids in the human lung: validation of new tools for the expression study of retinoid receptors.

Authors:  Stéphane Poulain; Stéphanie Lacomme; Shyue-Fang Battaglia-Hsu; Stanislas du Manoir; Lydia Brochin; Jean-Michel Vignaud; Nadine Martinet
Journal:  BMC Cancer       Date:  2009-12-04       Impact factor: 4.430

10.  Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A.

Authors:  Fei Ye; Xiao-Chun Xu
Journal:  Mol Cancer       Date:  2010-04-28       Impact factor: 27.401
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