| Literature DB >> 17188385 |
Hyukki Chang1, Tsuyoshi Saito, Nao Ohiwa, Masaru Tateoka, Custer C Deocaris, Takahiko Fujikawa, Hideaki Soya.
Abstract
Orexins, recognized for their diverse functions in sleep/wakefulness/arousal and appetite regulation, may play provocative roles in stress response. Although the PVN of the hypothalamus expresses an abundance of orexin-2 receptor (OX-2R), the involvement of OX-2R in regulating ACTH response to stress remains unclear. To address this, we examined effects of a selective antagonist to OX-2R (N-{(1S)-1-[6,7-dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl}-2,2-dimethylpropyl)-N-{4-pyridinylmethyl}amine upon plasma ACTH concentrations after administration of orexin A and swimming stress. Increases in ACTH levels with orexin A or swimming stress were attenuated with prior administration of an OX-2R antagonist. These results suggest that swimming stress facilitates ACTH release, at least in part via activation of OX-2R.Entities:
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Year: 2006 PMID： 17188385 DOI： 10.1016/j.neures.2006.11.009
Source DB: PubMed Journal: Neurosci Res ISSN： 0168-0102 Impact factor: 3.304