| Literature DB >> 17188352 |
Yumi Takasaki1, Masako Iwanaga, Kunihiro Tsukasaki, Miyuki Kusano, Kazuyuki Sugahara, Yasuaki Yamada, Shimeru Kamihira, Shuichi Ikeda, Masao Tomonaga.
Abstract
Multiple visceral involvements and various blood cell count abnormalities are frequently manifested in adult T-cell leukemia/lymphoma (ATLL) at diagnosis. We evaluated the effects of four visceral involvement (bone marrow (BM), skin, liver, spleen) and six blood cell count abnormalities (anemia, neutrophilia, thrombocytopenia, monocytosis, eosinophilia, basophilia) on the overall survival of 168 ATLL patients. In the aggressive type, BM involvement, skin involvement and monocytosis were significantly poor prognostic factors. Furthermore, concomitant involvement of BM and additional visceral organs worsened the prognosis. These data support that multiple organ involvements represent a poor prognostic factor for ATLL and provide clinical significance for BM examinations.Entities:
Mesh：
Year: 2006 PMID： 17188352 DOI： 10.1016/j.leukres.2006.11.013
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156