Literature DB >> 17188232

G protein coupled receptor structure and activation.

Brian K Kobilka1.   

Abstract

G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The members of this large family of membrane proteins are activated by a spectrum of structurally diverse ligands, and have been shown to modulate the activity of different signaling pathways in a ligand specific manner. In this manuscript I will review what is known about the structure and mechanism of activation of GPCRs focusing primarily on two model systems, rhodopsin and the beta(2) adrenoceptor.

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Year:  2006        PMID： 17188232      PMCID： PMC1876727          DOI： 10.1016/j.bbamem.2006.10.021

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  102 in total

Review 1.  Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs).

Authors:  D C Teller; T Okada; C A Behnke; K Palczewski; R E Stenkamp
Journal:  Biochemistry       Date:  2001-07-03       Impact factor: 3.162

Review 2.  Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking.

Authors:  L A Devi
Journal:  Trends Pharmacol Sci       Date:  2001-10       Impact factor: 14.819

3.  Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.

Authors:  F Knoflach; V Mutel; S Jolidon; J N Kew; P Malherbe; E Vieira; J Wichmann; J A Kemp
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

Review 4.  Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors.

Authors:  J A Ballesteros; L Shi; J A Javitch
Journal:  Mol Pharmacol       Date:  2001-07       Impact factor: 4.436

5.  Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals.

Authors:  David Salom; Isolde Le Trong; Ehmke Pohl; Juan A Ballesteros; Ronald E Stenkamp; Krzysztof Palczewski; David T Lodowski
Journal:  J Struct Biol       Date:  2006-06-02       Impact factor: 2.867

6.  Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor.

Authors:  P Ghanouni; Z Gryczynski; J J Steenhuis; T W Lee; D L Farrens; J R Lakowicz; B K Kobilka
Journal:  J Biol Chem       Date:  2001-04-24       Impact factor: 5.157

7.  Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.

Authors:  Xiaojie Yao; Charles Parnot; Xavier Deupi; Venkata R P Ratnala; Gayathri Swaminath; David Farrens; Brian Kobilka
Journal:  Nat Chem Biol       Date:  2006-06-25       Impact factor: 15.040

8.  Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor.

Authors:  Stuart D C Ward; Fadi F Hamdan; Lanh M Bloodworth; Nasir A Siddiqui; Jian Hua Li; Jürgen Wess
Journal:  Biochemistry       Date:  2006-01-24       Impact factor: 3.162

9.  Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 316 in helix 8 and residues in the sequence 60-75, covering the cytoplasmic end of helices TM1 and TM2 and their connection loop CL1.

Authors:  C Altenbach; J Klein-Seetharaman; K Cai; H G Khorana; W L Hubbell
Journal:  Biochemistry       Date:  2001-12-25       Impact factor: 3.162

10.  Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation.

Authors:  Christian E Elling; Thomas M Frimurer; Lars-Ole Gerlach; Rasmus Jorgensen; Birgitte Holst; Thue W Schwartz
Journal:  J Biol Chem       Date:  2006-03-27       Impact factor: 5.157
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  203 in total

1.  Oligomeric forms of G protein-coupled receptors (GPCRs).

Authors:  Krzysztof Palczewski
Journal:  Trends Biochem Sci       Date:  2010-06-09       Impact factor: 13.807

2.  Structural insights into human GPCR protein OA1: a computational perspective.

Authors:  Anirban Ghosh; Uddhavesh Sonavane; Sai Krishna Andhirka; Gopala Krishna Aradhyam; Rajendra Joshi
Journal:  J Mol Model       Date:  2011-09-22       Impact factor: 1.810

Review 3.  The significance of G protein-coupled receptor crystallography for drug discovery.

Authors:  John A Salon; David T Lodowski; Krzysztof Palczewski
Journal:  Pharmacol Rev       Date:  2011-12       Impact factor: 25.468

4.  Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations.

Authors:  Karola M Schlinkmann; Annemarie Honegger; Esin Türeci; Keith E Robison; Daša Lipovšek; Andreas Plückthun
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-04       Impact factor: 11.205

5.  FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models.

Authors:  Masato Takeuchi; Akira Hirasawa; Takafumi Hara; Ikuo Kimura; Tatsuya Hirano; Takayoshi Suzuki; Naoki Miyata; Takeo Awaji; Masaji Ishiguro; Gozoh Tsujimoto
Journal:  Br J Pharmacol       Date:  2013-04       Impact factor: 8.739

6.  Arrestin-rhodopsin binding stoichiometry in isolated rod outer segment membranes depends on the percentage of activated receptors.

Authors:  Martha E Sommer; Klaus Peter Hofmann; Martin Heck
Journal:  J Biol Chem       Date:  2010-12-17       Impact factor: 5.157

7.  Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.

Authors:  Baran A Ersoy; Leonardo Pardo; Sumei Zhang; Darren A Thompson; Glenn Millhauser; Cedric Govaerts; Christian Vaisse
Journal:  Nat Chem Biol       Date:  2012-06-24       Impact factor: 15.040

8.  Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of AT1R Initiated by van der Waals Attraction.

Authors:  Khuraijam Dhanachandra Singh; Hamiyet Unal; Russell Desnoyer; Sadashiva S Karnik
Journal:  J Chem Inf Model       Date:  2019-01-16       Impact factor: 4.956

9.  Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations.

Authors:  George Khelashvili; Alan Grossfield; Scott E Feller; Michael C Pitman; Harel Weinstein
Journal:  Proteins       Date:  2009-08-01

Review 10.  The Paracaspase MALT1.

Authors:  Janna Hachmann; Guy S Salvesen
Journal:  Biochimie       Date:  2015-09-16       Impact factor: 4.079
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