Literature DB >> 1718780

Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL6.

S Natsuka1, H Isshiki, S Akira, T Kishimoto.   

Abstract

The nuclear factor NF-IL6 had been suggested to be responsible for the IL-6-mediated induction of several acute-phase proteins. To obtain evidence for the involvement of NF-IL6 in the induction of acute-phase proteins, we introduced the NF-IL6 gene and its truncated mutant (delNFIL6) gene into a hepatoma cell line Hep3B. Then, we examined the effect of the overproduced NF-IL6 and delNFIL6 on the expression of haptoglobin, fibrinogen and albumin. As a result, basal production as well as induction of haptoglobin by IL-6 were augmented by the expression of NF-IL6, whereas delNFIL6 blocked the production of haptoglobin, fibrinogen and albumin.

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Year:  1991        PMID： 1718780     DOI： 10.1016/0014-5793(91)81103-f

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

Authors:  T Taga; M Narazaki; K Yasukawa; T Saito; D Miki; M Hamaguchi; S Davis; M Shoyab; G D Yancopoulos; T Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

2.  A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

Authors:  S Kinoshita; S Akira; T Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

3.  The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms.

Authors:  D P Ramji; A Vitelli; F Tronche; R Cortese; G Ciliberto
Journal:  Nucleic Acids Res       Date:  1993-01-25       Impact factor: 16.971

4.  Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells.

Authors:  R A Ramos; Y Nishio; A C Maiyar; K E Simon; C C Ridder; Y Ge; G L Firestone
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

5.  NF-IL6 represses early gene expression of human papillomavirus type 16 through binding to the noncoding region.

Authors:  S Kyo; M Inoue; Y Nishio; K Nakanishi; S Akira; H Inoue; M Yutsudo; O Tanizawa; A Hakura
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103

6.  A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction.

Authors:  Y Nishio; H Isshiki; T Kishimoto; S Akira
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

7.  Identification of an acute-phase reactant in murine infections with Trypanosoma brucei.

Authors:  S Z Shapiro; S J Black
Journal:  Infect Immun       Date:  1992-09       Impact factor: 3.441

8.  Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

Authors:  U M Wegenka; J Buschmann; C Lütticken; P C Heinrich; F Horn
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272

9.  Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA.

Authors:  S Harroch; M Revel; J Chebath
Journal:  EMBO J       Date:  1994-04-15       Impact factor: 11.598
  9 in total

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