| Literature DB >> 17187062 |
Marie-Liesse Asselin-Labat1, Kate D Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C Forrest, Lynne Hartley, Lorraine Robb, Frank G Grosveld, Jacqueline van der Wees, Geoffrey J Lindeman, Jane E Visvader.
Abstract
The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. To gain insight into the role of Gata-3 in breast epithelial development and oncogenesis, we have explored its normal function within the mammary gland by conditionally deleting Gata-3 at different stages of development. We report that Gata-3 has essential roles in the morphogenesis of the mammary gland in both the embryo and adult. Through the discovery of a novel marker (beta3-integrin) of luminal progenitor cells and their purification, we demonstrate that Gata-3 deficiency leads to an expansion of luminal progenitors and a concomitant block in differentiation. Remarkably, introduction of Gata-3 into a stem cell-enriched population induced maturation along the alveolar luminal lineage. These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation.Entities:
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Year: 2006 PMID： 17187062 DOI： 10.1038/ncb1530
Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824