BACKGROUND: A flexible needle-catheter tissue-anchoring device was developed to accomplish full-thickness tissue apposition of the GI wall. The aim of this study was to identify the performance of this device for repair of large iatrogenic gastric perforations in a porcine model. OBJECTIVES: Six pigs. DESIGN: Short-term survival animal study. SETTINGS: Pigs were studied while they were under general anesthesia. Device performance in differing gastric locations and wall thicknesses was assessed by 2 perforations more than 2 cm in size created for each pig along the greater curvature and the anterior wall. INTERVENTIONS: Each perforation was closed by parallel placement of tissue anchor sets sequentially along the length of the perforation. MAIN OUTCOME MEASUREMENTS: One week follow-up endoscopy and necropsy were performed. RESULTS: Twelve perforations were closed with the 48 tissue anchor sets. All animals survived for 1 week without clinical complications. Follow-up endoscopy and necropsy revealed that all tissue anchors remained with firmly held sutures and sealed perforations. CONCLUSIONS: Full-thickness closure with a new tissue-anchoring device simply and successfully repaired large iatrogenic gastric perforations.
BACKGROUND: A flexible needle-catheter tissue-anchoring device was developed to accomplish full-thickness tissue apposition of the GI wall. The aim of this study was to identify the performance of this device for repair of large iatrogenic gastric perforations in a porcine model. OBJECTIVES: Six pigs. DESIGN: Short-term survival animal study. SETTINGS: Pigs were studied while they were under general anesthesia. Device performance in differing gastric locations and wall thicknesses was assessed by 2 perforations more than 2 cm in size created for each pig along the greater curvature and the anterior wall. INTERVENTIONS: Each perforation was closed by parallel placement of tissue anchor sets sequentially along the length of the perforation. MAIN OUTCOME MEASUREMENTS: One week follow-up endoscopy and necropsy were performed. RESULTS: Twelve perforations were closed with the 48 tissue anchor sets. All animals survived for 1 week without clinical complications. Follow-up endoscopy and necropsy revealed that all tissue anchors remained with firmly held sutures and sealed perforations. CONCLUSIONS: Full-thickness closure with a new tissue-anchoring device simply and successfully repaired large iatrogenic gastric perforations.
Authors: Elizabeth Rajan; Christopher J Gostout; Matthew S Lurken; Nicholas J Talley; Giles R Locke; Lawrence A Szarka; Kazuki Sumiyama; Timothy A Bakken; Gary J Stoltz; Mary A Knipschield; Gianrico Farrugia Journal: Gastrointest Endosc Date: 2008-02-11 Impact factor: 9.427
Authors: Eric Mark Pauli; Randy S Haluck; Adrian M Ionescu; Ann M Rogers; Timothy R Shope; Matthew T Moyer; Arnab Biswas; Abraham Mathew Journal: Surg Endosc Date: 2009-12-24 Impact factor: 4.584
Authors: Sang Soo Lee; Brant K Oelschlager; Andrew S Wright; Renato V Soares; Huseyin Sinan; Martin I Montenovo; Joo Ha Hwang Journal: Surg Endosc Date: 2011-05-10 Impact factor: 4.584