Literature DB >> 17184879

Open-label pilot study of combination therapy with rosiglitazone and bexarotene in the treatment of cutaneous T-cell lymphoma.

Jacob A Sepmeyer1, John P Greer, Tatsuki Koyama, John A Zic.   

Abstract

Four patients with stable or progressive cutaneous T-cell lymphoma treated with oral bexarotene received oral rosiglitazone. After 16 weeks of combination therapy, skin score decreased in two patients. Pruritus was alleviated in 3 of 4 patients, whereas quality of life was unchanged. Adverse events included hyperlipidemia, anemia, neutropenia, and lymphopenia.

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Year:  2006        PMID: 17184879     DOI: 10.1016/j.jaad.2006.10.033

Source DB:  PubMed          Journal:  J Am Acad Dermatol        ISSN: 0190-9622            Impact factor:   11.527


  3 in total

Review 1.  Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

Authors:  Hong Sheng Cheng; Wei Ren Tan; Zun Siong Low; Charlie Marvalim; Justin Yin Hao Lee; Nguan Soon Tan
Journal:  Int J Mol Sci       Date:  2019-10-11       Impact factor: 5.923

Review 2.  Pruritus Reduction with Systemic Anti-lymphoma Treatments in Patients with Cutaneous T Cell Lymphoma: A Narrative Review.

Authors:  Halle Field; Ling Gao; Pooja Motwani; Henry K Wong
Journal:  Dermatol Ther (Heidelb)       Date:  2016-09-02

3.  Clinical Use of PPARgamma Ligands in Cancer.

Authors:  Jennifer L Hatton; Lisa D Yee
Journal:  PPAR Res       Date:  2008-12-18       Impact factor: 4.964

  3 in total

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