Literature DB >> 17183628

Changes in the slope of the CD4 cell count increase after initiation of potent antiretroviral treatment.

Ronald J Bosch1, Rui Wang, Florin Vaida, Michael M Lederman, Mary A Albrecht.   

Abstract

SUMMARY: Two phases of CD4+ T-cell increases are seen soon after potent antiretroviral therapy (ART) is initiated. In this 72-week analysis of 101 subjects with sustained viral suppression, we estimate the inflection point between the 2 phases to be 10 weeks after treatment initiation. Higher pretreatment HIV-1 RNA levels were associated with steeper initial CD4+ T-cell increases, likely reflecting greater redistribution of cells from lymphoid tissue to the peripheral blood compartment.

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Year:  2006        PMID： 17183628

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  11 in total

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