Literature DB >> 17182123

Regulation of Smad activities.

Lan Xu1.   

Abstract

TGF-beta (Transforming Growth Factor-beta) cytokines employ Smad proteins as the intracellular mediator of signaling. Upon TGF-beta stimulation, the cytoplasmic Smads become phosphorylated and consequently accumulate in the nucleus to regulate target gene expression. The cytoplasm-to-nucleus redistribution of Smads, as well as the ability of Smads to activate or repress gene transcription, is under multiple layers of regulation by factors not limited to TGF-beta. With recent advance in the knowledge of regulatory factors impinged on Smads, we are beginning to understand the complexity in cellular responses to TGF-beta.

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Year:  2006        PMID： 17182123      PMCID： PMC1805629          DOI： 10.1016/j.bbaexp.2006.11.001

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  107 in total

1.  Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus.

Authors:  P A Hoodless; T Tsukazaki; S Nishimatsu; L Attisano; J L Wrana; G H Thomsen
Journal:  Dev Biol       Date:  1999-03-15       Impact factor: 3.582

2.  Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways.

Authors:  Thomas Meyer; Andreas Begitt; Inga Lödige; Marleen van Rossum; Uwe Vinkemeier
Journal:  EMBO J       Date:  2002-02-01       Impact factor: 11.598

3.  Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.

Authors:  Wei He; David C Dorn; Hediye Erdjument-Bromage; Paul Tempst; Malcolm A S Moore; Joan Massagué
Journal:  Cell       Date:  2006-06-02       Impact factor: 41.582

4.  PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.

Authors:  Xia Lin; Xueyan Duan; Yao-Yun Liang; Ying Su; Katharine H Wrighton; Jianyin Long; Min Hu; Candi M Davis; Jinrong Wang; F Charles Brunicardi; Yigong Shi; Ye-Guang Chen; Anming Meng; Xin-Hua Feng
Journal:  Cell       Date:  2006-06-02       Impact factor: 41.582

5.  Physical and functional interaction of SMADs and p300/CBP.

Authors:  C Pouponnot; L Jayaraman; J Massagué
Journal:  J Biol Chem       Date:  1998-09-04       Impact factor: 5.157

Review 6.  Smads: transcriptional activators of TGF-beta responses.

Authors:  R Derynck; Y Zhang; X H Feng
Journal:  Cell       Date:  1998-12-11       Impact factor: 41.582

7.  Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner.

Authors:  A Kurisaki; S Kose; Y Yoneda; C H Heldin; A Moustakas
Journal:  Mol Biol Cell       Date:  2001-04       Impact factor: 4.138

8.  Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors.

Authors:  X H Feng; E H Filvaroff; R Derynck
Journal:  J Biol Chem       Date:  1995-10-13       Impact factor: 5.157

Review 9.  Importin-beta-like nuclear transport receptors.

Authors:  A C Ström; K Weis
Journal:  Genome Biol       Date:  2001-06-05       Impact factor: 13.583

10.  Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1.

Authors:  P A Wilson; G Lagna; A Suzuki; A Hemmati-Brivanlou
Journal:  Development       Date:  1997-08       Impact factor: 6.868
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  37 in total

1.  Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction.

Authors:  Piyush Tripathi; Yinqiu Wang; Adam M Casey; Feng Chen
Journal:  J Am Soc Nephrol       Date:  2012-01-26       Impact factor: 10.121

2.  Transcription factor Smad3 is required for the inhibition of adipogenesis by retinoic acid.

Authors:  François Marchildon; Catherine St-Louis; Rahima Akter; Victoria Roodman; Nadine L Wiper-Bergeron
Journal:  J Biol Chem       Date:  2010-02-23       Impact factor: 5.157

3.  Effects of Haobie Yangyin Ruanjian decoction on hepatic fibrosis induced by carbon tetrachloride in rats.

Authors:  Feng-Rui Yang; Bu-Wu Fang; Jian-Shi Lou
Journal:  World J Gastroenterol       Date:  2010-03-28       Impact factor: 5.742

4.  Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects.

Authors:  Qunshan Jia; Bradley W McDill; Song-Zhe Li; Chuxia Deng; Ching-Pin Chang; Feng Chen
Journal:  Dev Biol       Date:  2007-08-31       Impact factor: 3.582

5.  Flow-dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells.

Authors:  Robert D Shepherd; Stephanie M Kos; Kristina D Rinker
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-04-13       Impact factor: 4.733

6.  Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP).

Authors:  Le Wang; Yi-Tong Liu; Rui Hao; Lei Chen; Zhijie Chang; Hong-Rui Wang; Zhi-Xin Wang; Jia-Wei Wu
Journal:  J Biol Chem       Date:  2011-03-16       Impact factor: 5.157

Review 7.  The microRNA networks of TGFβ signaling in cancer.

Authors:  V P Sivadas; S Kannan
Journal:  Tumour Biol       Date:  2013-12-10

Review 8.  TGFbeta in Cancer.

Authors:  Joan Massagué
Journal:  Cell       Date:  2008-07-25       Impact factor: 41.582

9.  4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation.

Authors:  Rania Azar; Amandine Alard; Christiane Susini; Corinne Bousquet; Stéphane Pyronnet
Journal:  EMBO J       Date:  2009-10-15       Impact factor: 11.598

10.  BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses.

Authors:  Huchun Li; Masayuki Sekine; Seyha Seng; Shalom Avraham; Hava Karsenty Avraham
Journal:  PLoS One       Date:  2009-09-21       Impact factor: 3.240
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