OBJECTIVE: Total body irradiation (TBI) and cyclophosphamide (CY) during allogeneic stem cell transplantation (ASCT) cause salivary gland dysfunction in children. The aim of this investigation was to study the scintigraphic functional changes over time of the parotid and submandibular glands in children and young adults one year after treatment with CY and TBI at ASCT. METHODS: Salivary gland scintigraphy (SGS) was performed before ASCT, and 3-6 months and 12 months after ASCT. The three male patients who fulfilled the scintigraphic study had a mean age (+/- SD) of 17.3 +/- 9.8 years at ASCT. RESULTS: The parotid secretion capacity (SPar) was 83.5 +/- 3.2% before ASCT and 48.5 +/- 25.8% during the next 3-6 months (P < 0.05). The SPar did not increase (48.1 +/- 12.4%) during the rest of the first year after ASCT. The submandibular emptying capacity (SSub) was 91.3 +/- 12.9% before ASCT and 35.4 +/- 2.3% after 3-6 months (P < 0.05). The SSub was 87.9 +/- 17.9% one year after ASCT. CONCLUSIONS: The parotid glands were more sensitive to irradiation since they did not recover lost capacity to secrete saliva, while the submandibular glands recovered the secretion capacity at the one-year follow-up.
OBJECTIVE: Total body irradiation (TBI) and cyclophosphamide (CY) during allogeneic stem cell transplantation (ASCT) cause salivary gland dysfunction in children. The aim of this investigation was to study the scintigraphic functional changes over time of the parotid and submandibular glands in children and young adults one year after treatment with CY and TBI at ASCT. METHODS: Salivary gland scintigraphy (SGS) was performed before ASCT, and 3-6 months and 12 months after ASCT. The three male patients who fulfilled the scintigraphic study had a mean age (+/- SD) of 17.3 +/- 9.8 years at ASCT. RESULTS: The parotid secretion capacity (SPar) was 83.5 +/- 3.2% before ASCT and 48.5 +/- 25.8% during the next 3-6 months (P < 0.05). The SPar did not increase (48.1 +/- 12.4%) during the rest of the first year after ASCT. The submandibular emptying capacity (SSub) was 91.3 +/- 12.9% before ASCT and 35.4 +/- 2.3% after 3-6 months (P < 0.05). The SSub was 87.9 +/- 17.9% one year after ASCT. CONCLUSIONS: The parotid glands were more sensitive to irradiation since they did not recover lost capacity to secrete saliva, while the submandibular glands recovered the secretion capacity at the one-year follow-up.
Authors: I G M van der Pas-van Voskuilen; J S J Veerkamp; J E Raber-Durlacher; D Bresters; A J van Wijk; A Barasch; S McNeal; R A Th Gortzak Journal: Support Care Cancer Date: 2009-01-13 Impact factor: 3.603
Authors: Juliette Stolze; Jop C Teepen; Judith E Raber-Durlacher; Jacqueline J Loonen; Judith L Kok; Wim J E Tissing; Andrica C H de Vries; Sebastian J C M M Neggers; Eline van Dulmen-den Broeder; Marry M van den Heuvel-Eibrink; Helena J H van der Pal; A Birgitta Versluys; Margriet van der Heiden-van der Loo; Marloes Louwerens; Leontien C M Kremer; Henk S Brand; Dorine Bresters Journal: Cancers (Basel) Date: 2022-07-11 Impact factor: 6.575