Literature DB >> 17181172

Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists.

John Regan1, Thomas W Lee, Renée M Zindell, Younes Bekkali, Jörg Bentzien, Thomas Gilmore, Abdelhakim Hammach, Thomas M Kirrane, Alison J Kukulka, Daniel Kuzmich, Richard M Nelson, John R Proudfoot, Mark Ralph, Josephine Pelletier, Donald Souza, Lijiljana Zuvela-Jelaska, Gerald Nabozny, David S Thomson.   

Abstract

We report on the nuclear receptor binding affinities, cellular activities of transrepression and transactivation, and anti-inflammatory properties of a quinol-4-one and other A-ring mimetic containing nonsteroidal class of glucocorticoid agonists.

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Year:  2006        PMID： 17181172     DOI： 10.1021/jm061273t

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  2 in total

1.  Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.

Authors:  Christian Harcken; Doris Riether; Pingrong Liu; Hossein Razavi; Usha Patel; Thomas Lee; Todd Bosanac; Yancey Ward; Mark Ralph; Zhidong Chen; Donald Souza; Richard M Nelson; Alison Kukulka; Tazmeen N Fadra-Khan; Ljiljana Zuvela-Jelaska; Mita Patel; David S Thomson; Gerald H Nabozny
Journal:  ACS Med Chem Lett       Date:  2014-11-20       Impact factor: 4.345

Review 2.  Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents.

Authors:  A M Stranahan; Y Zhou; B Martin; S Maudsley
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530
  2 in total

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