| Literature DB >> 17181142 |
Maria C Breschi1, Vincenzo Calderone, Alma Martelli, Filippo Minutolo, Simona Rapposelli, Lara Testai, Federica Tonelli, Aldo Balsamo.
Abstract
This study was aimed at evaluating, on a limited number of benzopyran compounds, whether the insertion of an electron-rich spirocyclic substituent at the C4 carbon of the benzopyran molecular nucleus may improve the cardioprotective properties against ischemia. Some of the new compounds (1b, 2b, and 4b) exhibited interesting anti-ischemic properties without affecting significantly the blood pressure parameters.Entities:
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Year: 2006 PMID： 17181142 DOI： 10.1021/jm061228l
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446