Literature DB >> 17180078

CD95 (APO-1/Fas)-associating signalling proteins.

M E Peter1, F C Kischkel, S Hellbardt, A M Chinnaiyan, P H Krammer, V M Dixit.   

Abstract

The CD95 (APO-1/Fas) receptor has attracted great interest in recent years because it transduces an apoptotic signal in a variety of different tissues. CD95 belongs to the NGF/TNF-receptor superfamily, members of which need to be trimerized by specific protein ligands in order to generate a signal. This review focuses on recent advances in the understanding of the proximal signal transduction mechanism of CD95. The cloning of numerous proteins that interact with CD95 and other members of this receptor family and the in vivo identification of several proteins that associate with CD95 in a ligand-dependent fashion opens the way to delineate the death pathway and to explain crosstalk among these receptors on a molecular basis.

Entities:  

Year:  1996        PMID： 17180078

Source DB:  PubMed          Journal:  Cell Death Differ        ISSN： 1350-9047            Impact factor:   15.828


  9 in total

1.  Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis.

Authors:  T H Holmström; S E Tran; V L Johnson; N G Ahn; S C Chow; J E Eriksson
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

2.  Cif (Cytochrome c efflux-inducing factor) activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid.

Authors:  Z Han; K Bhalla; P Pantazis; E A Hendrickson; J H Wyche
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

Review 3.  Kinase inhibitors in cancer therapy: a look ahead.

Authors:  H H Sedlacek
Journal:  Drugs       Date:  2000-03       Impact factor: 9.546

4.  FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

Authors:  J P Medema; C Scaffidi; F C Kischkel; A Shevchenko; M Mann; P H Krammer; M E Peter
Journal:  EMBO J       Date:  1997-05-15       Impact factor: 11.598

5.  Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

Authors:  M Müller; S Strand; H Hug; E M Heinemann; H Walczak; W J Hofmann; W Stremmel; P H Krammer; P R Galle
Journal:  J Clin Invest       Date:  1997-02-01       Impact factor: 14.808

Review 6.  Caspases: the executioners of apoptosis.

Authors:  G M Cohen
Journal:  Biochem J       Date:  1997-08-15       Impact factor: 3.857

Review 7.  Apoptosis and (in) Pain-Potential Clinical Implications.

Authors:  Hugo Ribeiro; Ana Bela Sarmento-Ribeiro; José Paulo Andrade; Marília Dourado
Journal:  Biomedicines       Date:  2022-05-27

8.  Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells.

Authors:  Claudia Friesen; Annelie Lubatschofski; Jörg Kotzerke; Inga Buchmann; Sven N Reske; Klaus-Michael Debatin
Journal:  Eur J Nucl Med Mol Imaging       Date:  2003-06-26       Impact factor: 9.236

9.  CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis.

Authors:  A Algeciras; D H Dockrell; D H Lynch; C V Paya
Journal:  J Exp Med       Date:  1998-03-02       Impact factor: 14.307
  9 in total

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