Nancy Han1, Susan Galandiuk. 1. Section of Colon and Rectal Surgery, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA.
Abstract
OBJECTIVE: To review the application, outcome, and recent developments of neoadjuvant chemoradiation therapy with respect to rectal cancer. DATA SOURCES AND STUDY SELECTION: Articles written in English after 1980 selected from MEDLINE and PubMed from the National Library of Medicine. Case reports were excluded. There were no other criteria for exclusion of published information pertaining to this topic. DATA EXTRACTION AND SYNTHESIS: Articles were obtained and organized from MEDLINE and PubMed as well as the reference lists of pertinent literature. CONCLUSIONS: Published reports have demonstrated that neoadjuvant chemoradiation improves survival and decreases local recurrence in patients with stage II and III rectal cancers. It is anticipated that advances and technical developments in both chemotherapy and radiation therapy will lead to improved oncologic results with decreased toxic side effects.
OBJECTIVE: To review the application, outcome, and recent developments of neoadjuvant chemoradiation therapy with respect to rectal cancer. DATA SOURCES AND STUDY SELECTION: Articles written in English after 1980 selected from MEDLINE and PubMed from the National Library of Medicine. Case reports were excluded. There were no other criteria for exclusion of published information pertaining to this topic. DATA EXTRACTION AND SYNTHESIS: Articles were obtained and organized from MEDLINE and PubMed as well as the reference lists of pertinent literature. CONCLUSIONS: Published reports have demonstrated that neoadjuvant chemoradiation improves survival and decreases local recurrence in patients with stage II and III rectal cancers. It is anticipated that advances and technical developments in both chemotherapy and radiation therapy will lead to improved oncologic results with decreased toxic side effects.
Authors: Yon Kuei Lim; Wai Lun Law; Rico Liu; Jensen T C Poon; Joe F M Fan; Oswens S H Lo Journal: World J Surg Oncol Date: 2010-03-26 Impact factor: 2.754
Authors: David W Dietz; Farrokh Dehdashti; Perry W Grigsby; Robert S Malyapa; Robert J Myerson; Joel Picus; Jon Ritter; Jason S Lewis; Michael J Welch; Barry A Siegel Journal: Dis Colon Rectum Date: 2008-08-06 Impact factor: 4.585