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Literature DB >> 17178795

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

Poonpilas Hongmanee¹, Kamolchanok Rukseree, Benjamas Buabut, Boontiwa Somsri, Prasit Palittapongarnpim.

Abstract

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.

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Year: 2006 PMID： 17178795 PMCID： PMC1803129 DOI： 10.1128/AAC.01310-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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