Cyclic adenosine monophosphate antagonism of prostaglandin induced vasospasm.

Prostaglandin F2alpha was applied topically to the transclivally exposed basilar artery of the cat. The resultant vasoconstriction and its reversal by dibutyryl cyclic adenosine monophosphate was recorded photographically and measured, and the results analyzed statistically. Arterial BP, pCO2' pO2 and pH were determined to insure that the vascular responses were not due to any general physiological disturbance. The results indicated that Prostaglandin F2alpha is a powerful vasoconstrictive substance and that its effects are readily reversible by dibutyryl cyclic adenosine monophosphate.