| Literature DB >> 17178220 |
Vincent J Huber1, Mika Tsujita, Maya Yamazaki, Kenji Sakimura, Tsutomu Nakada.
Abstract
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions.Entities:
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Year: 2006 PMID： 17178220 DOI： 10.1016/j.bmcl.2006.12.010
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823