| Literature DB >> 17177896 |
Katri H Raitio1, Juha R Savinainen, Tapio Nevalainen, Tomi Järvinen, Jouko Vepsäläinen.
Abstract
Aliphatic amides of 7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxylic acid 6 were synthesized and evaluated for their CB2 and CB1 receptor activities by a [35S]GTPgammaS membrane-binding assay. Compounds 7-18 produced CB2 inverse agonist activities with a variety of potencies (IC50: 1 nm-1 microm). By contrast, no considerable antagonism of CB1 receptor was observed by 1-10 microm concentrations indicating that synthesized compounds were CB2 receptor selective.Entities:
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Year: 2006 PMID： 17177896 DOI： 10.1111/j.1747-0285.2006.00452.x
Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817