Literature DB >> 171770

Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth.

P A Insel, H R Bourne, P Coffino, G M Tomkins.   

Abstract

Dibutyryl cyclic adenosine 3',5'-monophosphate (cyclic AMP) produces phosphodiesterase induction, growth arrest, and cytolysis in S49 lymphoma cells. The striking parallelism between protein kinase activity that is dependent on cytosol cyclic AMP and cellular responses to dibutyryl cyclic AMP in wild-type cells and three classes of clones resistant to cyclic AMP indicates that protein kinase mediates cyclic AMP regulation of growth and enzyme induction in S49 cells.

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Year:  1975        PMID： 171770     DOI： 10.1126/science.171770

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  37 in total

1.  Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis.

Authors:  P A Rae; N S Gutmann; J Tsao; B P Schimmer
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

2.  Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A.

Authors:  Alexander C Zambon; Lingzhi Zhang; Simon Minovitsky; Joan R Kanter; Shyam Prabhakar; Nathan Salomonis; Karen Vranizan; Inna Dubchak; Bruce R Conklin; Paul A Insel
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-06       Impact factor: 11.205

3.  Protein kinase A-dependent binding of a nuclear factor to the 21-base-pair repeat of the human T-cell leukemia virus type I long terminal repeat.

Authors:  H T Poteat; F Y Chen; P Kadison; J G Sodroski; W A Haseltine
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

4.  Enhanced phosphorylation of many endogenous protein substrates in human fibroblasts transformed by simian virus 40.

Authors:  J Epstein; J L Breslow; J H Fontaine
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

5.  Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities.

Authors:  P A Insel; J Fenno
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

6.  Studies of cyclic AMP action using mutant tissue culture cells.

Authors:  P Coffino; H R Bourne; P A Insel; K L Melmon; G Johnson; J Vigne
Journal:  In Vitro       Date:  1978-01

7.  Activation of protein kinase A-independent pathways by Gs alpha in Drosophila.

Authors:  W J Wolfgang; I J Roberts; F Quan; C O'Kane; M Forte
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

8.  Catastrophe theory and cellular determination, transdetermination, and differentiation.

Authors:  A E Woodcock
Journal:  Bull Math Biol       Date:  1979       Impact factor: 1.758

9.  Revertants of an S49 cell mutant that expresses altered cyclic AMP-dependent protein kinase.

Authors:  T van Daalen Wetters; P Coffino
Journal:  Mol Cell Biol       Date:  1982-10       Impact factor: 4.272

10.  Growth of T-lymphoma cells in serum-free medium: lack of involvement of the cyclic AMP pathway in long-term cultures.

Authors:  F J Darfler; H Murakami; P A Insel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205
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