Literature DB >> 17176491

Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.

Martin Reuter1, Yvonne Kuepper, Juergen Hennig.   

Abstract

In a genetic association study the role of the -703 G/T (rs4570625) polymorphism, located in the promoter region of the tryptophan hydroxylase 2 gene (TPH2), in personality traits was investigated in a sample of 404 healthy Caucasian subjects. A significant association between harm avoidance (HA), a trait related to anxiety, and the -703 G/T polymorphism was detected supporting the findings by Gutknecht and colleagues.

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Year:  2006        PMID： 17176491     DOI： 10.1017/S1461145706007073

Source DB:  PubMed          Journal:  Int J Neuropsychopharmacol        ISSN： 1461-1457            Impact factor:   5.176


  22 in total

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6.  Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability.

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7.  A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder.

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Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2009-11-06       Impact factor: 5.270

8.  5'-Untranslated region of the tryptophan hydroxylase-2 gene harbors an asymmetric bidirectional promoter but not internal ribosome entry site in vitro.

Authors:  Guo-Lin Chen; Gregory M Miller
Journal:  Gene       Date:  2009-01-21       Impact factor: 3.688

9.  Associations between prefrontal γ-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women.

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10.  Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro.

Authors:  Guo-Lin Chen; Eric J Vallender; Gregory M Miller
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