Literature DB >> 17176221

Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats.

Harold L Newmark1, Mou-Tuan Huang, Bandaru S Reddy.   

Abstract

Gamma (gamma) tocopherol, but not alpha (alpha) tocopherol (vitamin E), has previously been reported as an effective inhibitor of cyclooxygenase (COX) enzyme activity. In a pilot study of 17 rats, mixed tocopherols containing more than 50% gamma-tocopherol, added at 0.1% to an AIN-76A diet, produced a significant inhibition (about 55%) of azoxymethane-induced aberrant crypt foci in the colon of rats. Mixed tocopherols also reduced tetradecanoyl phorbol acetate-induced ear inflammation in mice when topically applied.

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Year:  2006        PMID： 17176221     DOI： 10.1207/s15327914nc5601_11

Source DB:  PubMed          Journal:  Nutr Cancer        ISSN： 0163-5581            Impact factor:   2.900


  17 in total

1.  Gamma-tocopherol attenuates moderate but not severe colitis and suppresses moderate colitis-promoted colon tumorigenesis in mice.

Authors:  Qing Jiang; Ziying Jiang; Yava Jones Hall; Yumi Jang; Paul W Snyder; Carol Bain; Jianjie Huang; Amber Jannasch; Bruce Cooper; Yun Wang; Michelle Moreland
Journal:  Free Radic Biol Med       Date:  2013-09-04       Impact factor: 7.376

2.  δ-tocopherol is more active than α - or γ -tocopherol in inhibiting lung tumorigenesis in vivo.

Authors:  Guang-Xun Li; Mao-Jung Lee; Anna B Liu; Zhihong Yang; Yong Lin; Weichung J Shih; Chung S Yang
Journal:  Cancer Prev Res (Phila)       Date:  2011-03

3.  δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats.

Authors:  Fei Guan; Guangxun Li; Anna B Liu; Mao-Jung Lee; Zhihong Yang; Yu-Kuo Chen; Yong Lin; Weichung Shih; Chung S Yang
Journal:  Cancer Prev Res (Phila)       Date:  2012-02-24

Review 4.  Natural Forms of Vitamin E as Effective Agents for Cancer Prevention and Therapy.

Authors:  Qing Jiang
Journal:  Adv Nutr       Date:  2017-11-15       Impact factor: 8.701

5.  Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice.

Authors:  Yumi Jang; Na-Young Park; Agnetha Linn Rostgaard-Hansen; Jianjie Huang; Qing Jiang
Journal:  Free Radic Biol Med       Date:  2016-03-23       Impact factor: 7.376

6.  Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases.

Authors:  Qing Jiang; Xinmin Yin; Markus A Lill; Matthew L Danielson; Helene Freiser; Jianjie Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-11       Impact factor: 11.205

7.  A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth.

Authors:  Gang Lu; Hang Xiao; Guang-Xun Li; Sonia C Picinich; Yu-Kuo Chen; Anna Liu; Mao-Jung Lee; Shea Loy; Chung S Yang
Journal:  Carcinogenesis       Date:  2010-01-22       Impact factor: 4.944

8.  Inhibitory effects of different forms of tocopherols, tocopherol phosphates, and tocopherol quinones on growth of colon cancer cells.

Authors:  Sonia C Dolfi; Zhihong Yang; Mao-Jung Lee; Fei Guan; Jungil Hong; Chung S Yang
Journal:  J Agric Food Chem       Date:  2013-08-30       Impact factor: 5.279

9.  Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma.

Authors:  Hong Jin Lee; Jihyeung Ju; Shiby Paul; Jae-Young So; Andrew DeCastro; Amanda Smolarek; Mao-Jung Lee; Chung S Yang; Harold L Newmark; Nanjoo Suh
Journal:  Clin Cancer Res       Date:  2009-06-09       Impact factor: 12.531

10.  Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice.

Authors:  Avantika Barve; Tin Oo Khor; Sujit Nair; Kenneth Reuhl; Nanjoo Suh; Bandaru Reddy; Harold Newmark; Ah-Ng Kong
Journal:  Int J Cancer       Date:  2009-04-01       Impact factor: 7.396
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