Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Reversible binding of heme to proteins in cellular signal transduction.

Literature DB >> 17176030

Reversible binding of heme to proteins in cellular signal transduction.

Shangwei Hou¹, Mark F Reynolds, Frank T Horrigan, Stefan H Heinemann, Toshinori Hoshi.

Abstract

Heme plays critical roles in numerous biological phenomena. Recent evidence has uncovered a new role of heme in cellular signal transduction, and its mechanism involves reversible binding of heme to proteins. This Account highlights the novel function of heme as an intracellular messenger in the regulation of gene expression and ion channel function.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 17176030 DOI： 10.1021/ar040020w

Source DB: PubMed Journal: Acc Chem Res ISSN： 0001-4842 Impact factor: 22.384

Keyword Cloud
Cited

23 in total

1. Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity.

Authors: Fang Yang; Xian Xia; Hui-Yan Lei; En-Duo Wang
Journal: J Biol Chem Date: 2010-10-05 Impact factor: 5.157

2. Heme controls the regulation of protein tyrosine kinases Jak2 and Src.

Authors: Xiao Yao; Parimaladevi Balamurugan; Aaron Arvey; Christina Leslie; Li Zhang
Journal: Biochem Biophys Res Commun Date: 2010-10-29 Impact factor: 3.575

3. The 2-Cys peroxiredoxin alkyl hydroperoxide reductase c binds heme and participates in its intracellular availability in Streptococcus agalactiae.

Authors: Delphine Lechardeur; Annabelle Fernandez; Bruno Robert; Philippe Gaudu; Patrick Trieu-Cuot; Gilles Lamberet; Alexandra Gruss
Journal: J Biol Chem Date: 2010-03-22 Impact factor: 5.157

4. Heme Gazing: Illuminating Eukaryotic Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors.

Authors: David A Hanna; Osiris Martinez-Guzman; Amit R Reddi
Journal: Biochemistry Date: 2017-03-27 Impact factor: 3.162

5. The heme-regulatory motif of nuclear receptor Rev-erbβ is a key mediator of heme and redox signaling in circadian rhythm maintenance and metabolism.

Authors: Eric L Carter; Yanil Ramirez; Stephen W Ragsdale
Journal: J Biol Chem Date: 2017-05-12 Impact factor: 5.157

Reversible binding of heme to proteins in cellular signal transduction.

1. Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity.

2. Heme controls the regulation of protein tyrosine kinases Jak2 and Src.

3. The 2-Cys peroxiredoxin alkyl hydroperoxide reductase c binds heme and participates in its intracellular availability in Streptococcus agalactiae.

4. Heme Gazing: Illuminating Eukaryotic Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors.

5. The heme-regulatory motif of nuclear receptor Rev-erbβ is a key mediator of heme and redox signaling in circadian rhythm maintenance and metabolism.

6. Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors.

7. Regulation of intracellular heme trafficking revealed by subcellular reporters.

8. Heme and blood-feeding parasites: friends or foes?

Review 9. Trafficking of heme and porphyrins in metazoa.

10. A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase.