| Literature DB >> 17174939 |
Toru Fukuda1, Kazuhiro Kanomata, Junya Nojima, Itaru Urakawa, Tetsuo Suzawa, Mana Imada, Akiko Kukita, Ryutaro Kamijo, Takeyoshi Yamashita, Takenobu Katagiri.
Abstract
Fibroblast growth factor 23 (FGF23) is a key humoral factor in phosphate homeostasis and skeletogenesis, though the nature of its intracellular signaling is still unclear. Recently, Egr-1, a zinc-finger transcription factor, was identified as an immediate early response gene of FGF23 in the kidney. We report here, that FGF23 induces not only Egr-1 but also two isoforms of NAB2, which are specific co-repressors of Egr-1. Both isoforms of NAB2 induced by FGF23 were localized in the nucleus and suppressed the transcriptional activity of Egr-1. A negative feedback loop established by Egr-1 and NAB2 may thus be involved in mediating the physiological effects of FGF23.Entities:
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Year: 2006 PMID： 17174939 DOI： 10.1016/j.bbrc.2006.12.011
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575