| Literature DB >> 17174885 |
Seung-Hoi Koo1, Marc Montminy.
Abstract
Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. Studies by and now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1alpha.Entities:
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Year: 2006 PMID： 17174885 DOI： 10.1016/j.cell.2006.11.034
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582