| Literature DB >> 17174475 |
Cecilia Huerta1, Elena Sánchez-Ferrero, Eliecer Coto, Marta Blázquez, René Ribacoba, Luis M Guisasola, Carlos Salvador, Victoria Alvarez.
Abstract
Nitric oxide synthases (NOS) and mitochondrial DNA-polymorphisms have been associated with the risk of developing Parkinson's disease (PD). In this report, we genotyped 450 PD-patients and 200 controls for three polymorphisms in the endothelial, inducible and neuronal NOS-genes, and for the T4336C and A10398G mitochondrial DNA-polymorphisms. None of the eNOS (intron 4 VNTR), iNOS (exon 22 A/G), or nNOS (exon 29T/C) were significantly associated with PD. Mitochondrial 4336C increased the PD-risk among women (OR=6.13), while the 10398G had a protective effect (OR=0.52). We did not find significantly interactions between the NOS and mitochondrial polymorphisms in the risk for PD in our population.Entities:
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Year: 2006 PMID： 17174475 DOI： 10.1016/j.neulet.2006.11.044
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046