| Literature DB >> 17174364 |
Alain F Kamdem Waffo1, Philip H Coombes, Neil R Crouch, Dulcie A Mulholland, Sawsan M M El Amin, Peter J Smith.
Abstract
The combined hexane/CH(2)Cl(2) extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(gamma,gamma-dimethylallyloxy)acridone (tegerrardin B) (2), three known acridones (3-5), two known furoquinolines (6,7), and the acridone precursor tecleanone (8). Arborinine (3) and evoxine (6) displayed moderate antiplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 12.3 and 24.5 microM, respectively.Entities:
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Year: 2006 PMID： 17174364 DOI： 10.1016/j.phytochem.2006.10.011
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072