| Literature DB >> 17174125 |
Esther Vázquez1, Miguel A Valverde.
Abstract
Ion channel functional diversity can be achieved at the structural level by means of three main mechanisms: (1) transcriptional regulation and processing of mRNA, (2) heteromerization of different pore-forming channel subunits and (3) incorporation of regulatory subunits to the functional channel complex. In this review article we will focus on one of these mechanisms, alternative pre-mRNA splicing, in the context of the TRP superfamily of cation channels. For this purpose, the basic principles governing pre-mRNA splicing will be introduced and comprehensive tables classifying only published spliced-variants of TRP channels will be presented.Entities:
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Year: 2006 PMID： 17174125 DOI： 10.1016/j.semcdb.2006.11.004
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727