Literature DB >> 17174098

A new binary compound for the production of 124I via the 124Te(p,n)124I reaction.

Jonathon A Nye1, Miguel A Avila-Rodriguez, Robert J Nickles.   

Abstract

The binary compound, aluminum telluride (Al(2)Te(3)), was investigated as a target material for the production of (124)I by way of the (124)Te(p,n)(124)I reaction on a low-energy cyclotron. The high melting point and formation of a glassy matrix upon heating provided a stable target material at irradiations up to 20 microA of 11 MeV protons. The 87% tellurium mass fraction and 95% iodine separation yield led to significantly higher quantities of iodine compared to traditional TeO(2)/6%Al(2)O(3) admixtures. Radiochemical analysis of distilled samples using ion chromatography showed that the product remained in the iodide form while supported in weak buffer solutions. Stable Te impurities in the radioiodine product were less than 0.5 microg following purification by ion exchange chromatography. Average thick target yields of 229+/-18 microCi/microAh were achieved, and typical production runs at 18 microA for three hours yielded 12 mCi at the end-of-bombardment. Total losses of the target material after each irradiation and distillation cycle were approximately 2%.

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Year:  2006        PMID: 17174098     DOI: 10.1016/j.apradiso.2006.10.012

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN: 0969-8043            Impact factor:   1.513


  5 in total

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Authors:  Weijun Wei; Zachary T Rosenkrans; Jianjun Liu; Gang Huang; Quan-Yong Luo; Weibo Cai
Journal:  Chem Rev       Date:  2020-03-23       Impact factor: 60.622

2.  Improved production of 76Br, 77Br and 80mBr via CoSe cyclotron targets and vertical dry distillation.

Authors:  Paul A Ellison; Aeli P Olson; Todd E Barnhart; Sabrina L V Hoffman; Sean W Reilly; Mehran Makvandi; Jennifer L Bartels; Dhanabalan Murali; Onofre T DeJesus; Suzanne E Lapi; Bryan Bednarz; Robert J Nickles; Robert H Mach; Jonathan W Engle
Journal:  Nucl Med Biol       Date:  2019-09-05       Impact factor: 2.947

Review 3.  Iodine-124: a promising positron emitter for organic PET chemistry.

Authors:  Lena Koehler; Katherine Gagnon; Steve McQuarrie; Frank Wuest
Journal:  Molecules       Date:  2010-04-13       Impact factor: 4.411

Review 4.  Radiochemistry, Production Processes, Labeling Methods, and ImmunoPET Imaging Pharmaceuticals of Iodine-124.

Authors:  Krishan Kumar; Arijit Ghosh
Journal:  Molecules       Date:  2021-01-14       Impact factor: 4.411

Review 5.  124 Iodine: a longer-life positron emitter isotope-new opportunities in molecular imaging.

Authors:  Giuseppe Lucio Cascini; Artor Niccoli Asabella; Antonio Notaristefano; Antonino Restuccia; Cristina Ferrari; Domenico Rubini; Corinna Altini; Giuseppe Rubini
Journal:  Biomed Res Int       Date:  2014-05-08       Impact factor: 3.411

  5 in total

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