Literature DB >> 17174089

Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents.

Maojiang Wu1, Qiming Sun, Chunhao Yang, Dongdong Chen, Jian Ding, Yi Chen, Liping Lin, Yuyuan Xie.   

Abstract

A series of 4,5-disubstitute-1,2,3-thiadiazole compounds were designed and synthesized as potent anticancer agents, some of them exhibited excellent in vitro and in vivo inhibitory activity.

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Year:  2006        PMID： 17174089     DOI： 10.1016/j.bmcl.2006.11.060

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Delia Preti; Mojgan Aghazadeh Tabrizi; Andrea Brancale; Xian-Hua Fu; Jun Li; Su-Zhan Zhang; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2011-12-21       Impact factor: 7.446

2.  Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; Carlota Lopez Cara; Maria Dora Carrion; Andrea Brancale; Ernest Hamel; Longchuan Chen; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446

3.  An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins.

Authors:  George R Pettit; Mathew D Minardi; Fiona Hogan; Pat M Price
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

4.  Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues.

Authors:  Ganesh S Jedhe; Debasish Paul; Rajesh G Gonnade; Manas K Santra; Ernest Hamel; Tam Luong Nguyen; Gangadhar J Sanjayan
Journal:  Bioorg Med Chem Lett       Date:  2013-06-12       Impact factor: 2.823

5.  Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Andrea Brancale; Antonio Ricci; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2011-06-27       Impact factor: 7.446

Review 6.  Metastasis: recent discoveries and novel treatment strategies.

Authors:  Suzanne A Eccles; Danny R Welch
Journal:  Lancet       Date:  2007-05-19       Impact factor: 79.321

7.  Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Filippo Prencipe; Paola Oliva; Stefania Baraldi; Maria Kimatrai Salvador; Luisa Carlota Lopez-Cara; Andrea Brancale; Salvatore Ferla; Ernest Hamel; Roberto Ronca; Roberta Bortolozzi; Elena Mariotto; Elena Porcù; Giuseppe Basso; Giampietro Viola
Journal:  Sci Rep       Date:  2017-04-13       Impact factor: 4.379

8.  2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents.

Authors:  Erin Marie Kirwen; Tarun Batra; Chandrabose Karthikeyan; Girdhar Singh Deora; Vandana Rathore; Chaitanya Mulakayala; Naveen Mulakayala; Amy Catherine Nusbaum; Joel Chen; Haneen Amawi; Kyle McIntosh; Neelam Shivnath; Deepak Chowarsia; Nisha Sharma; Md Arshad; Piyush Trivedi; Amit K Tiwari
Journal:  Acta Pharm Sin B       Date:  2016-08-06       Impact factor: 11.413

9.  I2/DMSO-Catalyzed Transformation of N-tosylhydrazones to 1,2,3-thiadiazoles.

Authors:  Weiwei Li; Jun Zhang; Jing He; Liang Xu; Luigi Vaccaro; Ping Liu; Yanlong Gu
Journal:  Front Chem       Date:  2020-06-12       Impact factor: 5.221

10.  Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3',4',5'-Trimethoxyphenyl)-2-Aryl-1H-Imidazole.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Filippo Prencipe; Paola Oliva; Stefania Baraldi; Mojgan Aghazadeh Tabrizi; Luisa Carlota Lopez-Cara; Salvatore Ferla; Andrea Brancale; Ernest Hamel; Roberto Ronca; Roberta Bortolozzi; Elena Mariotto; Giuseppe Basso; Giampietro Viola
Journal:  Sci Rep       Date:  2016-05-24       Impact factor: 4.379
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