Literature DB >> 1717309

Loss of virulence of canine distemper virus is associated with a structural change recognized by a monoclonal antibody.

D Hamburger1, C Griot, A Zurbriggen, C Orvell, M Vandevelde.   

Abstract

The monoclonal antibody (mAB) L1, which binds to the nucleocapsid protein of canine distemper virus (CDV), was shown to bind to avirulent CDV obtained after serial passages in Vero cells, but not to two different virulent demyelinating CDV-strains propagated in dog glial cell cultures. However, when both virulent CDV-strains were passaged through Vero cells they expressed, after a number of passages, an epitope recognized by mAB L1. The occurrence of the L1 epitope appeared to coincide with loss of virulence in animal inoculation experiments.

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Year:  1991        PMID： 1717309     DOI： 10.1007/bf01922469

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

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Authors:  T G Morrison
Journal:  Virus Res       Date:  1988-05       Impact factor: 3.303

2.  Preparation and characterization of monoclonal antibodies directed against four structural components of canine distemper virus.

Authors:  C Orvell; H Sheshberadaran; E Norrby
Journal:  J Gen Virol       Date:  1985-03       Impact factor: 3.891

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Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

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Journal:  Am J Vet Res       Date:  1969-07       Impact factor: 1.156

Review 5.  The mutation rate and variability of eukaryotic viruses: an analytical review.

Authors:  D B Smith; S C Inglis
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6.  Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment.

Authors:  B N Fields; M I Greene
Journal:  Nature       Date:  1982-11-04       Impact factor: 49.962

7.  Use of alveolar macrophages for cultivation of canine distemper virus.

Authors:  M J Appel; O R Jones
Journal:  Proc Soc Exp Biol Med       Date:  1967-11

8.  Monoclonal antibodies to a virulent strain of transmissible gastroenteritis virus: comparison of reactivity with virulent and attenuated virus.

Authors:  S K Welch; L J Saif
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

9.  Morphological and immunocytochemical characterisation of mixed glial cell cultures derived from neonatal canine brain.

Authors:  A Zurbriggen; M Vandevelde; C F Beranek; A Steck
Journal:  Res Vet Sci       Date:  1984-05       Impact factor: 2.534

10.  Antigenic variants of rabies virus.

Authors:  T J Wiktor; H Koprowski
Journal:  J Exp Med       Date:  1980-07-01       Impact factor: 14.307
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  8 in total

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Authors:  V von Messling; G Zimmer; G Herrler; L Haas; R Cattaneo
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Authors:  A Zurbriggen; H U Graber; A Wagner; M Vandevelde
Journal:  J Virol       Date:  1995-03       Impact factor: 5.103

6.  Morbillivirus glycoprotein expression induces ER stress, alters Ca2+ homeostasis and results in the release of vasostatin.

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Journal:  PLoS One       Date:  2012-03-05       Impact factor: 3.240

7.  Canine distemper virus-induced depletion of uninfected lymphocytes is associated with apoptosis.

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Journal:  Vet Immunol Immunopathol       Date:  2005-03-10       Impact factor: 2.046

8.  Establishment of canine and feline cells expressing canine signaling lymphocyte activation molecule for canine distemper virus study.

Authors:  Hitoshi Nakano; Yuki Kameo; Kiyohiko Andoh; Yoshito Ohno; Masami Mochizuki; Ken Maeda
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  8 in total

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