Autophagic cell death and its importance for fungal developmental biology and pathogenesis.

In order to cause disease in plants, many fungal pathogens develop a specialized structure called an appressorium. We have recently shown that the rice blast fungus Magnaporthe grisea undergoes a regulated form of programmed cell death during appressorium development involving autophagy. Significantly, this form of cell death is a prerequisite for plant infection and fungal pathogenesis and part of a growing body of evidence implicating autophagy as a key process in fungal developmental biology.