Literature DB >> 1717272

Autoantibodies against the beta-adrenergic receptor in human myocarditis and dilated cardiomyopathy: beta-adrenergic agonism without desensitization.

G Wallukat1, M Morwinski, K Kowal, A Förster, V Boewer, A Wollenberger.   

Abstract

The serum of patients with myocarditis and dilated cardiomyopathy contains immunoglobulins capable of causing in vitro acceleration of beating of neonatal rat heart myocytes. This effect is stereoselectively inhibited by (-)-propranolol and is inhibited also by the beta 1-selective adrenergic antagonists, bisoprolol and metoprolol. This effect is not reversed by washing and continues unabated for at least 24 h.

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Year:  1991        PMID: 1717272     DOI: 10.1093/eurheartj/12.suppl_d.178

Source DB:  PubMed          Journal:  Eur Heart J        ISSN: 0195-668X            Impact factor:   29.983


  22 in total

1.  Foreword to special issue on "Myocarditis".

Authors:  Alida L P Caforio
Journal:  Heart Fail Rev       Date:  2013-11       Impact factor: 4.214

2.  Autoimmune hypertensive syndrome.

Authors:  David C Kem; Xichun Yu; Eugene Patterson; Shijun Huang; Stavros Stavrakis; Bela Szabo; Leann Olansky; Jon McCauley; Madeleine W Cunningham
Journal:  Hypertension       Date:  2007-10-08       Impact factor: 10.190

Review 3.  Characterization of anti-heart M2 muscarinic receptor antibodies--a combined clinical and experimental study.

Authors:  M L Fu
Journal:  Mol Cell Biochem       Date:  1996 Oct-Nov       Impact factor: 3.396

Review 4.  [Therapy of dilated cardiomyopathies with and without inflammation].

Authors:  G Hufnagel; S Pankuweit; B Maisch
Journal:  Med Klin (Munich)       Date:  1998-04-15

Review 5.  Recognition and optimum management of myocarditis.

Authors:  A L Caforio; W J McKenna
Journal:  Drugs       Date:  1996-10       Impact factor: 9.546

Review 6.  Role of autoimmunity in dilated cardiomyopathy.

Authors:  A L Caforio
Journal:  Br Heart J       Date:  1994-12

Review 7.  Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases.

Authors:  Gerd Wallukat; Ingolf Schimke
Journal:  Semin Immunopathol       Date:  2014-04-29       Impact factor: 9.623

8.  Implications of a vasodilatory human monoclonal autoantibody in postural hypotension.

Authors:  Hongliang Li; Jonathan Zuccolo; David C Kem; Caitlin Zillner; Jiyeon Lee; Kenneth Smith; Judith A James; Madeleine W Cunningham; Xichun Yu
Journal:  J Biol Chem       Date:  2013-09-16       Impact factor: 5.157

Review 9.  Unresolved issues in theories of autoimmune disease using myocarditis as a framework.

Authors:  Robert Root-Bernstein; DeLisa Fairweather
Journal:  J Theor Biol       Date:  2014-12-04       Impact factor: 2.691

Review 10.  Cardiac troponins and autoimmunity: their role in the pathogenesis of myocarditis and of heart failure.

Authors:  Ziya Kaya; Hugo A Katus; Noel R Rose
Journal:  Clin Immunol       Date:  2009-05-14       Impact factor: 3.969

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