Literature DB >> 17172582

Is Crohn's disease due to defective immunity?

J R Korzenik1.   

Abstract

The understanding of the pathophysiology of Crohn's disease is currently undergoing a reassessment. The concept of this disease as a primary T cell disorder is being questioned, with a new emphasis on the role of innate immunity in initiating early events and in perpetuating the inflammatory state. Crohn's disease has been proposed instead to result from impaired innate immunity, encompassing the mucosal barrier and cellular elements including neutrophils and macrophages. Recent advances in genetics, functional studies on innate immunity and therapeutic trials on patients with Crohn's disease have lent support to this evolving hypothesis.

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Year:  2007        PMID： 17172582      PMCID： PMC1856647          DOI： 10.1136/gut.2006.095588

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  45 in total

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3.  The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease.

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4.  Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease.

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6.  An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease.

Authors:  J R Korzenik; B K Dieckgraefe
Journal:  Aliment Pharmacol Ther       Date:  2005-02-15       Impact factor: 8.171

7.  Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.

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Review 8.  Current status of genetics research in inflammatory bowel disease.

Authors:  S Vermeire; P Rutgeerts
Journal:  Genes Immun       Date:  2005-12       Impact factor: 2.676

9.  Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease.

Authors:  A Darfeuille-Michaud; C Neut; N Barnich; E Lederman; P Di Martino; P Desreumaux; L Gambiez; B Joly; A Cortot; J F Colombel
Journal:  Gastroenterology       Date:  1998-12       Impact factor: 22.682

10.  The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells.

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Journal:  J Immunol       Date:  1998-10-01       Impact factor: 5.422
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  26 in total

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2.  Mucormycosis of the intestine: a rare complication in Crohn's disease.

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Journal:  Gastroenterol Hepatol (N Y)       Date:  2012-02

3.  The role of innate immunity in Crohn's disease.

Authors:  Joshua Korzenik
Journal:  Gastroenterol Hepatol (N Y)       Date:  2007-02

4.  Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies.

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Authors:  Lori A Button; Stephen E Roberts; Michael J Goldacre; Ashley Akbari; Sarah E Rodgers; John G Williams
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Review 6.  Microbial host interactions in IBD: implications for pathogenesis and therapy.

Authors:  R Balfour Sartor; Marcus Muehlbauer
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8.  Perioperative Blood Transfusion and Postoperative Outcome in Patients with Crohn's Disease Undergoing Primary Ileocolonic Resection in the "Biological Era".

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9.  Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn's Disease Patients.

Authors:  Giuseppina Liguori; Bruno Lamas; Mathias L Richard; Giovanni Brandi; Gregory da Costa; Thomas W Hoffmann; Massimo Pierluigi Di Simone; Carlo Calabrese; Gilberto Poggioli; Philippe Langella; Massimo Campieri; Harry Sokol
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Review 10.  Revisiting Crohn's disease as a primary immunodeficiency of macrophages.

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