BACKGROUND: Small lesions to rostral versus caudal portions of the hand representation in the primary motor cortex (M1) produce different behavioral deficits. The goal of the present study was to determine if rehabilitative training has similar effects on functional topography of the spared M1 after rostral versus previously reported caudal M1 lesions. METHODS: Following a lesion to the rostral M1 hand area, monkeys were trained for 1 h/day for 30 days to retrieve food pellets from small wells using their impaired hand. Electrophysiological maps of the M1 were derived in anesthetized monkeys before infarct and after rehabilitative training using intracortical microstimulation. RESULTS: After a lesion to the rostral M1 and rehabilitative training, the size of the spared hand representation decreased 1.2%. This change is not statistically different from the 9% increase seen after caudal M1 lesion and rehabilitative training (P > 0.2). CONCLUSION: Postlesion training spares peri-infarct hand area regardless of whether the lesion is in the rostral or caudal M1.
BACKGROUND: Small lesions to rostral versus caudal portions of the hand representation in the primary motor cortex (M1) produce different behavioral deficits. The goal of the present study was to determine if rehabilitative training has similar effects on functional topography of the spared M1 after rostral versus previously reported caudal M1 lesions. METHODS: Following a lesion to the rostral M1 hand area, monkeys were trained for 1 h/day for 30 days to retrieve food pellets from small wells using their impaired hand. Electrophysiological maps of the M1 were derived in anesthetized monkeys before infarct and after rehabilitative training using intracortical microstimulation. RESULTS: After a lesion to the rostral M1 and rehabilitative training, the size of the spared hand representation decreased 1.2%. This change is not statistically different from the 9% increase seen after caudal M1 lesion and rehabilitative training (P > 0.2). CONCLUSION: Postlesion training spares peri-infarct hand area regardless of whether the lesion is in the rostral or caudal M1.
Authors: Tara L Moore; Monica A Pessina; Seth P Finklestein; Ronald J Killiany; Bethany Bowley; Larry Benowitz; Douglas L Rosene Journal: Restor Neurol Neurosci Date: 2016-09-21 Impact factor: 2.406
Authors: Monica A Maldonado; Rachel P Allred; Erik L Felthauser; Theresa A Jones Journal: Neurorehabil Neural Repair Date: 2007-12-11 Impact factor: 3.919
Authors: Adjia Hamadjida; Alexander F Wyss; Anis Mir; Martin E Schwab; Abderaouf Belhaj-Saif; Eric M Rouiller Journal: Exp Brain Res Date: 2012-09-19 Impact factor: 1.972
Authors: Gert Kwakkel; Carel G M Meskers; Erwin E van Wegen; Guus J Lankhorst; Alexander C H Geurts; Annet A van Kuijk; Eline Lindeman; Anne Visser-Meily; Erwin de Vlugt; J Hans Arendzen Journal: BMC Neurol Date: 2008-12-17 Impact factor: 2.474
Authors: Daniel J O'Shea; Paul Kalanithi; Emily A Ferenczi; Brian Hsueh; Chandramouli Chandrasekaran; Werapong Goo; Ilka Diester; Charu Ramakrishnan; Matthew T Kaufman; Stephen I Ryu; Kristen W Yeom; Karl Deisseroth; Krishna V Shenoy Journal: Sci Rep Date: 2018-04-30 Impact factor: 4.379