BACKGROUND: The causative role of alcohol consumption in renal disease is controversial, and its effect on renal graft and recipient survival has not been previously studied. METHODS: We analysed the association between pre-transplant [at the time of end-stage renal disease (ESRD) onset] alcohol dependency and renal graft and recipient survival. The United States Renal Data System (USRDS) records of kidney transplant recipients 18 years or older transplanted between 1 January 1995 and 31 December 2002 were examined. We used Kaplan-Meier analysis and Cox regression models adjusted for covariates to analyse the association between pre-transplant alcohol dependency and graft and recipient survival. RESULTS: In an entire study cohort of 60 523, we identified 425 patients with a history of alcohol dependency. Using Cox models, alcohol dependency was found to be associated with increased risk of death-censored graft failure [hazard ratio (HR) 1.38, P < 0.05] and increased risk of transplant recipient death (HR 1.56, P < 0.001). Subgroup analysis demonstrated an association of alcohol-dependency with recipient survival and death-censored graft survival in males (but not in females), and in both white and non-white racial subgroups. CONCLUSIONS: We concluded that alcohol dependency at the time of ESRD onset is a risk factor for renal graft failure and recipient death.
BACKGROUND: The causative role of alcohol consumption in renal disease is controversial, and its effect on renal graft and recipient survival has not been previously studied. METHODS: We analysed the association between pre-transplant [at the time of end-stage renal disease (ESRD) onset] alcohol dependency and renal graft and recipient survival. The United States Renal Data System (USRDS) records of kidney transplant recipients 18 years or older transplanted between 1 January 1995 and 31 December 2002 were examined. We used Kaplan-Meier analysis and Cox regression models adjusted for covariates to analyse the association between pre-transplant alcohol dependency and graft and recipient survival. RESULTS: In an entire study cohort of 60 523, we identified 425 patients with a history of alcohol dependency. Using Cox models, alcohol dependency was found to be associated with increased risk of death-censored graft failure [hazard ratio (HR) 1.38, P < 0.05] and increased risk of transplant recipient death (HR 1.56, P < 0.001). Subgroup analysis demonstrated an association of alcohol-dependency with recipient survival and death-censored graft survival in males (but not in females), and in both white and non-white racial subgroups. CONCLUSIONS: We concluded that alcohol dependency at the time of ESRD onset is a risk factor for renal graft failure and recipient death.
Authors: Jesse D Schold; Laura D Buccini; Michael W Kattan; David A Goldfarb; Stuart M Flechner; Titte R Srinivas; Emilio D Poggio; Richard Fatica; Liise K Kayler; Ashwini R Sehgal Journal: Arch Surg Date: 2012-06
Authors: Richelle N DeBlasio; Larissa Myaskovsky; Andrea F DiMartini; Emilee Croswell; Donna M Posluszny; Chethan Puttarajappa; Galen E Switzer; Ron Shapiro; Annette J DeVito Dabbs; Amit D Tevar; Sundaram Hariharan; Mary Amanda Dew Journal: Transplantation Date: 2022-04-01 Impact factor: 5.385
Authors: J D Schold; E L G Heaphy; L D Buccini; E D Poggio; T R Srinivas; D A Goldfarb; S M Flechner; J R Rodrigue; J D Thornton; A R Sehgal Journal: Am J Transplant Date: 2013-08-22 Impact factor: 8.086
Authors: Alexander Goldfarb-Rumyantzev; Anna Barenbaum; James Rodrigue; Preeti Rout; Ross Isaacs; Kenneth Mukamal Journal: Arch Med Sci Date: 2011-09-02 Impact factor: 3.318