Literature DB >> 1717212

Effects of cyclosporin A and FK506 on ischemia/reperfusion-induced neutrophil infiltration in the cat.

P Kubes1, J Hunter, D N Granger.   

Abstract

Isolated segments of cat small intestine were subjected to 3 hr of ischemia followed by 1 hr reperfusion (I/R). Mucosal biopsies were obtained for measurement of myeloperoxidase (MPO) activity, an index of tissue neutrophil count, and leukotriene B4 (LTB4) production. Animals were pretreated with either cyclosporin A (CsA) or FK506, which are potent immunosuppressants. Both agents significantly attenuated the neutrophil infiltration induced by I/R. FK506, but not CsA, reduced the elevated mucosal LTB4 production normally observed following reperfusion. The results of this study suggest that FK506 and CsA may be important agents in modulating neutrophil infiltration in acute inflammatory conditions.

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Year:  1991        PMID： 1717212     DOI： 10.1007/bf01296817

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  30 in total

1.  Inhibition of leucocyte chemotaxis by immunosuppressive drugs: an important mode of action?

Authors:  L F Wang; D H Adams; E Elias; J M Neuberger
Journal:  Transplant Proc       Date:  1990-10       Impact factor: 1.066

Review 2.  Intestinal transplantation: current status.

Authors:  D Grant
Journal:  Transplant Proc       Date:  1989-02       Impact factor: 1.066

3.  FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

Authors:  T Kino; H Hatanaka; S Miyata; N Inamura; M Nishiyama; T Yajima; T Goto; M Okuhara; M Kohsaka; H Aoki
Journal:  J Antibiot (Tokyo)       Date:  1987-09       Impact factor: 2.649

4.  Platelet-activating factor and cellular immune responses.

Authors:  P Braquet; M Rola-Pleszcynski
Journal:  Immunol Today       Date:  1987

5.  Comparative studies on the immunosuppressive activity of FK506, 15-deoxyspergualin, and cyclosporine.

Authors:  T Ochiai; K Nakajima; K Sakamoto; M Nagata; Y Gunji; T Asano; K Isono; T Sakamaki; K Hamaguchi
Journal:  Transplant Proc       Date:  1989-02       Impact factor: 1.066

6.  Blood levels of FK506 after intramuscular and intravenous administration in dogs.

Authors:  T Morimoto; F Yamada; T Kobayashi; K Iwasaki; M Sunada; J Sakamoto; S Miyaishi; H Takagi
Journal:  Transplant Proc       Date:  1989-02       Impact factor: 1.066

7.  Comparative studies of FK506 and cyclosporine in canine orthotopic hepatic allograft survival.

Authors:  K Yokota; T Takishima; K Sato; T Osakabe; Y Nakayama; H Uchida; K Aso; Y Masaki; M Ohbu; M Okudaira
Journal:  Transplant Proc       Date:  1989-02       Impact factor: 1.066

8.  Mucosal arachidonate metabolism and intestinal ischemia-reperfusion injury.

Authors:  M J Mangino; C B Anderson; M K Murphy; E Brunt; J Turk
Journal:  Am J Physiol       Date:  1989-08

9.  Latent inhibition of granulocyte function by cyclosporine A.

Authors:  G Kolb; I Eckle; K Bittner; T Müller; K Havemann; H Lange
Journal:  Immunobiology       Date:  1990-08       Impact factor: 3.144

10.  Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.

Authors:  D Bunjes; C Hardt; M Röllinghoff; H Wagner
Journal:  Eur J Immunol       Date:  1981-08       Impact factor: 5.532
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  8 in total

1.  Rho-kinase signalling regulates CXC chemokine formation and leukocyte recruitment in colonic ischemia-reperfusion.

Authors:  Stefan Santen; Yusheng Wang; Matthias W Laschke; Michael D Menger; Bengt Jeppsson; Henrik Thorlacius
Journal:  Int J Colorectal Dis       Date:  2010-07-01       Impact factor: 2.571

Review 2.  Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research.

Authors:  Liara M Gonzalez; Adam J Moeser; Anthony T Blikslager
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2014-11-20       Impact factor: 4.052

3.  Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin.

Authors:  S N Murthy; H S Cooper; H Shim; R S Shah; S A Ibrahim; D J Sedergran
Journal:  Dig Dis Sci       Date:  1993-09       Impact factor: 3.199

Review 4.  Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation.

Authors:  D H Peters; A Fitton; G L Plosker; D Faulds
Journal:  Drugs       Date:  1993-10       Impact factor: 9.546

5.  Suppression of local and systemic responses in streptococcal cell wall-induced acute inflammation of the air pouch by cyclosporine A. Comparison with the effects of two anti-inflammatory bis-benzimidazoles.

Authors:  J Dieter Geratz; K B Pryzwansky; J H Schwab; S K Anderle; R R Tidwell
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

6.  Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats.

Authors:  T Matsumoto; M Iida; S Nakamura; K Hizawa; F Kuroki; M Fujishima
Journal:  Dig Dis Sci       Date:  1994-04       Impact factor: 3.199

7.  Effects of FK506, an immunosuppressive agent, on genesis of water-immersion stress-induced gastric lesions in rats.

Authors:  E Hamajima; S Sugiyama; H Hoshino; H Goto; Y Tsukamoto; T Ozawa
Journal:  Dig Dis Sci       Date:  1994-04       Impact factor: 3.199

8.  Suppression of inflammation by cyclosporin A is mediated via a T lymphocyte-independent process.

Authors:  T E Miller; G Findon; D J Ormrod
Journal:  Pharm Res       Date:  1992-10       Impact factor: 4.200
  8 in total

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