| Literature DB >> 17170717 |
Abstract
Keloids are cosmetically devastating lesions with considerable morbidity. Ghazizadeh et al. document enhanced expression of IL-6 and its receptors in keloid fibroblasts, with a concomitant increase in collagen biosynthesis. Anti-IL-6 antibodies or blocking the IL-6 receptors elicits reduced collagen synthesis, suggesting a role for IL-6 in the regulation of collagen gene expression. These observations imply the feasibility of a pharmacologic platform, based on the targeting of the IL-6 signaling pathway, in keloids.Entities:
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Year: 2007 PMID： 17170717 DOI： 10.1038/sj.jid.5700604
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551