Literature DB >> 1717039

Induction of basic fibroblast growth factor in Alzheimer's disease pathology.

F Gómez-Pinilla1, B J Cummings, C W Cotman.   

Abstract

Alzheimer's disease (AD) and its hallmark, plaques, may be due to an imbalance of trophic support. It has been suggested that plaque biogenesis may involve a growth factor which induces sprouting of neurites to form plaques. Thus, we studied the distribution of basic fibroblast growth factor (bFGF), in the hippocampus from AD brain and in rodent brain after entorhinal ablation. Both cases have a partial deafferentation of the hippocampus. The strongest bFGF immunoreactivity in AD was shown in plaques of the dentate gyrus. Rodent brains showed a lesion-induced increase of bFGF in the dentate gyrus, primarily localized to astrocytes. Our results indicate that bFGF may serve an important biological function in plaques and possibly attract neurites.

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Year:  1990        PMID： 1717039     DOI： 10.1097/00001756-199011000-00009

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  17 in total

Review 1.  The role of cell cycle-mediated events in Alzheimer's disease.

Authors:  A K Raina; M J Monteiro; A McShea; M A Smith
Journal:  Int J Exp Pathol       Date:  1999-04       Impact factor: 1.925

2.  Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.

Authors:  G Perry; P Cras; S L Siedlak; M Tabaton; M Kawai
Journal:  Am J Pathol       Date:  1992-02       Impact factor: 4.307

Review 3.  The role of the amyloid protein precursor (APP) in Alzheimer's disease: does the normal function of APP explain the topography of neurodegeneration?

Authors:  D H Small
Journal:  Neurochem Res       Date:  1998-05       Impact factor: 3.996

4.  Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

Authors:  A McShea; P L Harris; K R Webster; A F Wahl; M A Smith
Journal:  Am J Pathol       Date:  1997-06       Impact factor: 4.307

Review 5.  New insights into the role of fibroblast growth factors in Alzheimer's disease.

Authors:  Ramy Alam; Yara Mrad; Hussein Hammoud; Zahraa Saker; Youssef Fares; Elias Estephan; Hisham F Bahmad; Hayat Harati; Sanaa Nabha
Journal:  Mol Biol Rep       Date:  2021-11-03       Impact factor: 2.316

6.  Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway.

Authors:  Ru-Rong Ji; Yasuhiko Kawasaki; Zhi-Ye Zhuang; Yeong-Ray Wen; Isabelle Decosterd
Journal:  Neuron Glia Biol       Date:  2006-11

Review 7.  Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling.

Authors:  O S Jørgensen
Journal:  Neurochem Res       Date:  1995-05       Impact factor: 3.996

8.  Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus.

Authors:  E Masliah; W G Honer; M Mallory; M Voigt; P Kushner; L Hansen; R Terry
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

9.  Frontiers in the pathogenesis of Alzheimer's disease.

Authors:  Kumar Sambamurti; K S Jagannatha Rao; Miguel A Pappolla
Journal:  Indian J Psychiatry       Date:  2009-01       Impact factor: 1.759

10.  Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer's disease.

Authors:  Naomi Nihonmatsu-Kikuchi; Xiu-Jun Yu; Yoshiki Matsuda; Nobuyuki Ozawa; Taeko Ito; Kazuhito Satou; Tadashi Kaname; Yasushi Iwasaki; Akio Akagi; Mari Yoshida; Shuta Toru; Katsuiku Hirokawa; Akihiko Takashima; Masato Hasegawa; Toshiki Uchihara; Yoshitaka Tatebayashi
Journal:  Commun Biol       Date:  2021-07-15
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