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Literature DB >> 17169757

Molecular biology of testicular germ cell tumors.

Abstract

Testicular germ cell tumors (TCGT) comprise a heterogeneous group of neoplasms, although all of them are originated from common precursors related to germ cell lineage. Understanding of normal development of germinal cells is essential to define new markers for diagnosis, prognostic subgroups and targeted therapies. Recent advances related to cytogenetic and molecular features have established the role of immunohistochemistry of c-kit, OCT-3/4 and determination of gain of chromosome 12 in the daily workup of premalignant lesions and invasive tumors. This review summarizes the current knowledge in the field of molecular biology of TGCT.

Entities: Disease Gene

Mesh：

Substances：
Biomarkers, Tumor

Year: 2006 PMID： 17169757 DOI： 10.1007/s12094-006-0147-0

Source DB: PubMed Journal: Clin Transl Oncol ISSN： 1699-048X Impact factor: 3.405

33 in total

1. Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2-p12.1.

Authors: S Rodriguez; O Jafer; H Goker; B M Summersgill; G Zafarana; A J M Gillis; R J H L M van Gurp; J W Oosterhuis; Y-J Lu; R Huddart; C S Cooper; J Clark; L H J Looijenga; J M Shipley
Journal: Oncogene Date: 2003-03-27 Impact factor: 9.867

2. Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes.

Authors: Véronique Bourdon; Félix Naef; Pulivarthi H Rao; Victor Reuter; Samuel C Mok; George J Bosl; Sanjay Koul; Vundaralli V V S Murty; Raju S Kucherlapati; R S K Chaganti
Journal: Cancer Res Date: 2002-11-01 Impact factor: 12.701

3. Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.

Authors: H Roelofs; M C Mostert; K Pompe; G Zafarana; M van Oorschot; R J van Gurp; A J Gillis; H Stoop; B Beverloo; J W Oosterhuis; C Bokemeyer; L H Looijenga
Journal: Am J Pathol Date: 2000-10 Impact factor: 4.307

Review 4. Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockouts.

Authors: K L Loveland; S Schlatt
Journal: J Endocrinol Date: 1997-06 Impact factor: 4.286

5. Detection of numerical and structural chromosome abnormalities in pediatric germ cell tumors by means of interphase cytogenetics.

Authors: C Stock; I M Ambros; T Lion; O A Haas; A Zoubek; H Gadner; P F Ambros
Journal: Genes Chromosomes Cancer Date: 1994-09 Impact factor: 5.006

6. Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors.

Authors: R J Sinke; D O Weghuis; R F Suijkerbuijk; A Tanigami; Y Nakamura; C Larsson; G Weber; B de Jong; J W Oosterhuis; W M Molenaar
Journal: Cancer Genet Cytogenet Date: 1994-03

7. CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminoma.

Authors: Xavier Leroy; David Augusto; Emmanuelle Leteurtre; Bernard Gosselin
Journal: J Histochem Cytochem Date: 2002-02 Impact factor: 2.479

8. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors.

Authors: Leendert H J Looijenga; Hans Stoop; Hubert P J C de Leeuw; Carlos A de Gouveia Brazao; Ad J M Gillis; Kees E P van Roozendaal; Everardus J J van Zoelen; Rob F A Weber; Katja P Wolffenbuttel; Herman van Dekken; Friedemann Honecker; Carsten Bokemeyer; Elizabeth J Perlman; Dominik T Schneider; Juha Kononen; Guido Sauter; J Wolter Oosterhuis
Journal: Cancer Res Date: 2003-05-01 Impact factor: 12.701